@article {Albera1281, author = {Albera, C and Ghio, P and Solidoro, P and Mabritto, I and Marchetti, L and Pozzi, E}, title ={激活和记忆肺泡t淋巴细胞在特发性嗜酸性肺炎},volume = {8}, number = {8}, pages ={1281—1285},year = {1995}, publisher = {European Respiratory Society},188bet官网地址为了研究t淋巴细胞可能参与特发性嗜酸性粒细胞性肺炎(IEP)的免疫发病机制,我们评估了6例症状性IEP患者外周血和肺泡淋巴细胞的表型特征,以及24例健康的非吸烟者作为对照。采用支气管肺泡灌洗(BAL)、单克隆抗体和流式细胞术。在IEP中,总和分化细胞计数显示轻度肺泡炎,嗜酸性粒细胞百分比和数量增加;肺泡淋巴细胞计数也增加。BAL组CD4+和CD8+淋巴细胞总数均显著增加;CD4+细胞表达早期(CD25)活化抗原。与健康对照组相比,IEP患者中CD45R0、CD45RA和CD62L共表达的分析显示,肺泡中CD4+细胞的积累显示表型库,通常由记忆t细胞表达(CD45R0+、CD45RA-、CD62L-)。CD8+肺泡淋巴细胞活化抗原共表达无明显增加。循环淋巴细胞没有明显增加,仅表现出明显升高的CD25表达。 These data suggest that a pivotal role is played by activated and memory CD4+ alveolar lymphocytes in IEP patients.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/8/8/1281}, eprint = {//www.qdcxjkg.com/content/8/8/1281.full.pdf}, journal = {European Respiratory Journal} }