％0刊期刊文章％一个罗伊，一个leblanc，c％a paquette，l％a ghezzo，h％的cote，j％a cartier，a％的malo，jl％t皮肤在高剂量处理的哮喘受试者中瘀伤吸入类固醇：频率和肾上腺功能的关联％D 1996％J欧洲呼吸轴颈％P 226-231％V 9％N 2％X高剂量吸入皮质类固醇（ICS）（预烯酮和BECLO-甲基>或= 800微克.Day-1）通常用于治疗哮喘。一些调查人员提出了皮肤影响（瘀伤）的证据，这表明系统性吸收。本研究旨在评估皮肤瘀伤的患病率，将皮肤瘀伤的发生与肾上腺皮质功能相关，并确定皮肤瘀伤的危险因素。在哮喘诊所招募了患有高剂量（800-2,000微克，800-2,000微克，800-20微克-1）的一百个成年哮喘受试者，并从眼科门诊诊所招募了100名对性和年龄的治疗受试者。施用了关于哮喘，一般习性和皮肤病变的详细问卷。进行皮肤检查。连续两天评估尿cortisol水平。评估血皮质醇水平和对Cortrosyn注射的反应（60分钟测试）。包括一百名成人哮喘（66名女性和34名男性），73次Enclomethasone和27次在预裂解中。 The prevalence of skin bruising was 71% based on the questionnaire (32% in controls) and 48% (39 out of 81 subjects) based on direct examination of the skin. We found a satisfactory association between the response to questionnaire and examination of the skin. Adrenocortical function testing showed that a minority of subjects (14 with at least one abnormal test) had lower urinary or blood cortisol levels. These low cortisol levels occurred in subjects who reported skin bruising. By multiple logistic regression, being a female (odds ratio (OR) = 20; 95% confidence interval (95% CI) = 13-33) and taking ICS for asthma (OR = 12; 95% CI = 8-18) were significantly (t = 5.4) related to the likelihood of developing skin bruising. In addition, among the asthmatic subjects, being older (OR = 1.6; 95% CI = 1.1-2.4/10 yrs interval) (t = 2.3) and being a female (OR = 22; 95% CI = 7-75) (t = 5.0) influenced the occurrence of skin bruising as documented by questionnaire. In asthmatic subjects, taking high doses of ICS is associated with: 1) increased occurrence of skin bruising by comparison with controls, particularly in older subjects; and 2) a generally normal adrenocortical function, although this function is significantly lower in subjects reporting skin bruising. %U //www.qdcxjkg.com/content/erj/9/2/226.full.pdf