RT杂志文章SR电子T1大肺和生长激素:肺泡数量增加?JF欧洲呼吸杂志JO Eur Respir J FD欧洲呼吸学会SP 938 OP 947 DO 10188bet官网地址.1183/09031936.95.08060938 VO 8 IS 6 A1 PM Donnelly A1 RR Grunstein A1 JK Peat A1 AJ Woolcock A1 PT Bye YR 1995 UL //www.qdcxjkg.com/content/8/6/938.abstract AB先前的生理学研究表明，肢端肥大症患者肺生长的增加与正常或高于正常的肺转移因子相关。这些发现可以解释为，在这种情况下，肺泡肥大或增生是肺生长的机制。由于通风的空气空间保持正常的弹性特性，我们想确定肢端肥大症患者肺生长的机制是否是肺泡数量增加而不是大小增加的结果。比较了不吸烟、肢端肥大症和正常男性和女性肺大小增加和不增加的肺扩张度(K)(肺泡大小的指数)、弹性后坐力、单呼吸一氧化碳转移系数和一氧化碳转移系数(KCO)、肺毛细血管血容量和肺泡膜扩散能力以及胸宽。无论肺大小如何，所有研究组的肺转移因子均正常。然而，KCO与所有受试者的总肺活量(预测%)呈负相关，而男性的KCO(预测%)与胸宽呈负相关。对于肺大的受试者，肺毛细血管血容量(预测%)与总肺活量(预测%)呈负相关。肺扩张力(K)、膜扩散能力、弹性后坐力均在正常范围内。这些发现表明，大肺受试者的肺泡大小、肺泡膜表面积和机械功能正常。 They also suggest that KCO may not be a reliable guide to the interpretation of the mechanism of lung growth in individuals with disproportionately large lungs, and may be reduced because not all the alveoli are perfused. The normal values for pulmonary distensibility found in all our individuals with large lungs, including acromegalics, suggest that lung growth has been achieved by an increased alveolar number rather than size. However, morphometric studies of the lungs of nonsmoking, acromegalic subjects without lung disease, are required to substantiate this finding.