％0期刊文章％a llewellyn-Jones，CG％a Johnson，mm％A Mitchell，Jl％a pye，a％a okafor，vc％a hill，sl a stockley a stockley a stockley，ra％t in Vivo in Vivo in Vivo in Vivo in nrchiectasisissisissisissisississississississississississississississississississis inthacisis in ronchiectisis in n in n in a pye。：对中性粒细胞功能和肺分泌％D 1995％j欧洲呼吸期刊％p 1479-1487％v 8％n 9％x支气管扩张与含有高水平的蛋白水解酶弹性酶有关，这被认为参与疾病的发病机理。抑制嗜中性粒细胞功能并干扰嗜中性粒细胞释放酶的药物可能对此类疾病的发展和发展具有有益的作用。我们已经研究了九名临床稳定支气管扩张患者的非甾体抗炎药吲哚美辛对中性粒细胞功能的影响。在研究期间，所有患者在临床上保持稳定。我们观察到周围嗜中性粒细胞趋化性显着降低至10 nmol.l-1 N- 1 N-甲基甲基 - 甲基 - 葡萄糖基 - 苯基丙氨酸（FMLP），从平均19.86（SEM 1.35）到8.46（0.68）（0.68）Cells.fields。治疗。通过静止和FMLP刺激的中性粒细胞的纤连蛋白降解也显着降低，从治疗开始时的平均1.90（0.19）微克x 3 x 10（5）细胞到4周后4周（0.87（0.08）微克）从3.17（0.35）微克到1.48（0.05）微克。 There was no effect on spontaneous or stimulated superoxide anion generation by neutrophils. Despite the marked changes in peripheral neutrophil function, no adverse effect was observed on viable bacterial load in the bronchial secretions. In addition, there was no difference in sputum albumin, elastase or myeloperoxidase levels, and only minor changes in the chemotactic activity of the sputum. These results suggest that nonsteroidal anti-inflammatory agents have a major effect on peripheral neutrophil function but do not appear to have an adverse effect on bacterial colonization of the airways. %U //www.qdcxjkg.com/content/erj/8/9/1479.full.pdf