Ty-jour t1 - Fenea-pigs中fenspiride的抗痉挛和抗刺脉络癌作用JF - 欧洲呼吸杂志Jo - Eur Respir J SP - 1699 LP - 1704 VL - 8是 - 10 Au - Laude，EA Au - Bee，D Au - Crambes，o au - howard，p y1 - 1995/10/01 ur - //www.qdcxjkg.com/content/8/10/1699.abstract n2 - fenspiride是一种非甾体抗炎剂，我们以前有过显示在豚鼠中有一个体内抗刺脉电池动作。我们目前使用麻醉豚鼠的约束仪物质P，神经蛋白A，柠檬酸和辣椒素研究了这一动作。据报道，Fenspiride尚未促进患者咳嗽的主观改善。我们使用了一种咳嗽的有意识的几内亚猪模型，作为一种更明确的方法，以研究Fenspiride对辣椒素和柠檬酸诱导的咳嗽的影响。雾化Fenspiride（1mg.ml-1）引起了辣椒素诱导的支气管内瘤瘤逆转的58％;和i.v.fenspiride（1mg.kg-1）45％逆转柠檬酸诱导支气管混凝土。物质p-和neurokinin a诱导的支气管混合物未受1 mg.kg-1 i.v的影响。fenspiride。 Aerosolized fenspiride (1, 3 and 10 mg.mL-1) administered for 4 min reduced citric acid (300 mM) induced cough, but 0.1 mg.mL-1 was without effect. Pretreatment with aerosolized fenspiride (10 mg.mL-1) caused a shift in the citric acid dose response curve to the right. For citric acid-induced cough, the duration of action of aerosolized fenspiride (10 mg.mL-1) was found to be 5 and 15 min post-treatment. Aerosolized capsaicin (30 microM) induced cough was also reduced by 3 and 10 mg.mL-1 aerosolized fenspiride, but no significant effect was found with 1 mg.mL-1. We conclude that aerosolized fenspiride reduces capsaicin- and citric acid-induced bronchoconstriction as well as induced cough in guinea-pigs in vivo. Whether a pathway common to both cough and bronchoconstriction is the site of action of fenspiride remains to be established. We postulate that fenspiride, acting as an antitussive and antibronchoconstrictor agent, would be beneficial in the clinical situation for those patients with hyperresponsive airways. ER -