TY - JOUR T1 -支气管肺泡灌洗前胶原- iii肽在新发过敏性肺炎中的应用:相关性与细胞外基质组件JF -欧洲呼吸杂志》乔欧元和J SP - 709 LP - 714 - 10.1183 / 09031936.93.06050709六世- 6 - 5盟Teschler H AU -汤普森,AB非盟-波尔,WR盟——都N AU -雷纳德,如果非盟- Costabel U Y1 - 1993/05/01 UR - //www.qdcxjkg.com/content/6/5/709.abstract N2 -过敏性肺炎(HP)的特征是肺实质炎症细胞的积累,并可能发展为肝纤维化。HP患者支气管肺泡灌洗液中成纤维细胞源性胶原代谢物前胶原- iii肽(PCP-III)含量增加。先前的研究表明，在新近发病的HP患者的BAL液中，成纤维细胞黏附分子、玻璃连蛋白和纤维连蛋白升高。鉴于这些观察结果，我们假设PCP-III的增加可能与近期未治疗HP患者的BAL液中玻璃体蛋白和纤维连接蛋白的增加有关。14例HP患者和9例正常对照组行BAL。PCP-III的氨基末端结构域采用放射免疫法测定，玻璃蛋白和纤维连接蛋白采用酶联免疫吸附法测定。在所有HP患者中均可见到BAL PCP-III的检测量，但在正常对照组中没有(平均值+/- SEM 5.1 +/- 1.2 vs <0.2 ng.ml-1;即低于PCP-III检测的检测限)。 The BAL fluid concentration of PCP-III correlated well with the amount of vitronectin (r = 0.638) and fibronectin (r = 0.710). Except for PCP-III and mast cells, no significant correlations were found between PCP-III, vitronectin, fibronectin and the cellular parameters. The findings suggest that an increased turnover of collagens and proteoglycans is present in the lower respiratory tract of patients with recent onset HP, possibly reflecting remodelling of the extracellular matrix. ER -