PT -期刊文章盟志盟——Andoh, Y盟——Haraguchi M盟——Shirato K TI -连续性气道杯状细胞和管腔内的粘液的支气管哮喘患者的气道DP - 1996年7月01 TA -欧洲呼吸杂志》第六PG - 1395 - 1401 - 9 IP - 7 4099 - //www.qdcxjkg.com/content/9/7/1395.short 4100 - //www.qdcxjkg.com/content/9/7/1395.full所以欧元和J1996 7月01;9 AB -本研究的目的是阐明在支气管哮喘患者的尸检肺中观察到的广泛粘液堵塞的形成机制。我们对8例支气管哮喘(BA组)患者的尸检肺气道进行了形态计量学分析，并与6例慢性支气管炎(CB组)和4例对照组(control)进行了比较。石蜡切片测量以下参数:支气管腺体与支气管壁的体积比例(Gland%);杯状细胞颗粒占总上皮层的比例(杯状%);腔内黏液以黏液占用率(MOR)表示;连续有杯状细胞的腔内黏液与腔内黏液总量的体积比(Vc/Vtol %);连续有杯状细胞的腔内黏液接触表面与腔内总表面的比值(Sc/Stot %)。BA组和CB组气道壁上Gland%、Goblet %、MOR或炎性细胞数均高于对照组。BA组与CB组的Gland%、Goblet %、MOR、炎性细胞数均无显著性差异，但嗜酸性粒细胞数除外:Gland%分别为23 +/- 3,22 +/- 3和6 +/- 2%; 22 +/- 9, 5 +/- 4 and 2 +/- 2% in Goblet%; 10 +/- 3, 18 +/- 3 and 0.3 +/- 0.5% in MOR; 199 +/- 68, 10 +/- 3 and 2 +/- 2 cells. mm-2 in eosinophil number of the peripheral airways from Groups BA, CB and Control, respectively. In contrast, marked and significant increases were observed both in Vc/Vtot% and Sc/Stot% in Group BA compared to Groups CB and Control both in central and peripheral airways: i.e. Vc/Vtot% in the peripheral airways was 53 +/- 5, 4 +/- 3 and 0.8 +/- 0.8% from Groups BA, CB and Control, respectively (BA vs CB or BA vs Control, p < 0.01 each). These findings suggest that the continuity of goblet cells and intraluminal mucus or lack of full release of mucus, from goblet cells, is peculiar to asthmatic airways, and may contribute to the formation of mucous-plugs.