@Article {de groot2100129，作者= {de groot，鲁汶cornelis anthonie和cristina astev {\〜a} o，Silvia和Meyer sauteur，Patrick Michael和Perkasa，Aditya和Hoogenboezem，Theo和Spuesens，Emiel Benny Margriet和Verhagen，LillyMaria And Van Rossum，Anna Maria Christiane和Unger，Wendy Wilhelmina Josephina}，Title = {支原体肺炎托运蒸发诱导保护粘膜抗体}，Elocation-Id = {2100129}，年= {2021}，DOI = {10.1183 / 13993003.00129出版商= {欧洲呼吸社会}，摘要= {支原188bet官网地址体肺炎是为社区肺炎住院儿童肺炎的最常见的细菌原因。通过疫苗预防感染可能是出现抗性M.肺炎肺炎的重要策略。然而，对M.肺炎的免疫反应知识有限，使疫苗设计复杂化。因此，我们研究了M.肺炎肺炎感染和无症状的抗体反应。在栖息的案例对照研究（N = 80）的M.肺炎肺携带者和匹配的对照中，我们观察到M.肺炎的携带者不会导致升级粘膜或全身肺炎肺炎特异性抗体，即使经过几个月的持续支架。我们在第二个队列（n = 69）中复制了这一发现，并发现在肺炎肺炎社区获得的肺炎期间，M.肺炎肺炎的粘膜水平明显增加。体外粘合测定显示，儿科患者的鼻腔分泌物中的高水平肺炎肺炎患者特异性抗体阻止了M.肺炎对呼吸上皮细胞的粘附。结论，我们的研究表明，肺炎肺炎特异性粘膜抗体防止细菌保护对呼吸上皮细胞的粘附性，并且仅在肺炎肺炎感染期间诱导，而不是在无症状的托架期间。这与含有细菌的细菌如肺炎链球菌的肺炎，其中粘膜抗体被细菌运输诱导。欧洲呼吸杂志的出版物最近被接受了粘膜抗体。 It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Ruben CornelisConflict of interest: Dr. de Groot has nothing to disclose.Conflict of interest: Silvia CristinaConflict of interest: Dr. Estev{\~a}o has nothing to disclose.Conflict of interest: Dr. Meyer Sauteur has nothing to disclose.Conflict of interest: Dr. Perkasa has nothing to disclose.Conflict of interest: Dr. Hoogenboezem has nothing to disclose.Conflict of interest: Dr. Spuesens has nothing to disclose.Conflict of interest: Dr. Verhagen has nothing to disclose.Conflict of interest: Dr. van Rossum has nothing to disclose.Conflict of interest: Dr. Unger has nothing to disclose.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/early/2021/08/12/13993003.00129-2021}, eprint = {//www.qdcxjkg.com/content/early/2021/08/12/13993003.00129-2021.full.pdf}, journal = {European Respiratory Journal} }