Ty-jour t1 - 急性呼吸窘迫综合征与肺泡巨噬细胞效率有关的JF - 欧洲呼吸期刊Jo - Eur Respir J Do - 10.1183 / 13993003 - 2100829 Au - Mahida，Rahul Y. Au - Scott，Aaron Au -Parekh，Dhruv Au - Lugg，Sebastian T. Au - Hardy，Rowan S. Au - Lavery，Gareth G. Au - Matthay，Michael A. Au - Naidu，Babu Au - Perkins，Gavin D. Au - Childett，David R.Y1 - 2021/01/01 UR - //www.qdcxjkg.com/content/early/2021/05/06/13993003.00829-2021.Abstract n2 - 急性呼吸窘迫综合征（ARDS）是肺部的炎症障碍，脓毒症作为主要的缓解学。尽管通风策略进展，中度至严重ARDS的死亡率均为40-46％[1]。ARDS与中性粒细胞流入肺泡。支气管 - 肺泡灌洗（BAL）流体中的持续高嗜嗜中性粒细胞和低肺泡巨噬细胞（AM）数与更大的死亡率相关[2]。虽然早期ARDS的炎症性肺泡环境最初延迟细胞凋亡，但这些中性粒细胞最终会在肺泡中进行凋亡[3]。AMS的凋亡中性粒细胞的有效癫痫症对于分辨炎症至关重要[3]。凋亡中性粒细胞可能在ARDS中累积，因为缺血性致效应和/或效力细胞效能均匀的效力，然后经历次要坏死，将炎症介质释放到肺泡间隙[4]中。这可能有助于在ARDS中观察到的长期炎症。 No study has previously assessed AM efferocytosis in ARDS, however monocyte-derived macrophages (MDMs) from ARDS patients do have impaired efferocytosis [5]. We investigated whether ARDS patients have impaired AM efferocytosis and increased alveolar neutrophil apoptosis.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Mahida has nothing to disclose.Conflict of interest: Dr. Scott has nothing to disclose.Conflict of interest: Dr. Parekh has nothing to disclose.Conflict of interest: Dr. Lugg has nothing to disclose.Conflict of interest: Dr. Hardy has nothing to disclose.Conflict of interest: Dr. Lavery has nothing to disclose.Conflict of interest: Dr. Matthay has nothing to disclose.Conflict of interest: Dr. Naidu has nothing to disclose.Conflict of interest: Dr. Perkins has nothing to disclose.Conflict of interest: Dr. Thickett has nothing to disclose. ER -