TY - JOUR T1 -主要腹部或胸部手术后自动闭环 vs 标准手动供氧:国际多中心随机对照研究摩根富林明-欧洲呼吸杂志》乔和J - 10.1183/13993003.00182 -2020欧元六世- 57 - 1 SP - 2000182 AU - L是什么,该款盟——贾比尔,萨米尔盟——Verzilli丹尼尔AU -雅各布,克利斯朵夫盟——Huiban林盟——Futier Emmanuel AU - Kerforne,托马斯•AU - PateauVictoire AU - Bouchard, Pierre-Alexandre AU - Consigny, Maëlys AU - Lellouche, François Y1 - 2011/01/01 UR - //www.qdcxjkg.com/content/57/1/2000182.abstract N2 - Introduction手术后可能出现低氧血症和高氧血症，并伴有相关并发症。这项多中心随机试验评估了高危腹部或胸部手术后自动闭环给氧的影响，在目标范围内通过脉搏血氧测量时间来优化氧饱和度。方法拔管后，有中至高危术后肺部并发症的患者随机分为“标准”或“自动”闭环供氧。主要结果是3天内氧合范围内的时间百分比。次要结果是在含氧条件下低氧血症和高氧血症的时间。结果200例患者中，自动化组的范围内时间均高于自动化组(初始≤3 h;91.4±13.7% vs 40.2±35.1%，差异+51.0% (95% CI−42.8-59.2%);在3天期间(94.0±11.3% vs 62.1±23.3%，差异+31.9% (95% CI 26.3-37.4%);术中,0.0001)。 Periods of hypoxaemia were reduced in the automated group (≤3 days; 32.6±57.8 min (1.2±1.9%) versus 370.5±594.3 min (5.0±11.2%), difference −10.2% (95% CI −13.9–−6.6%); p<0.0001), as well as hyperoxaemia under oxygen (≤3 days; 5.1±10.9 min (4.8±11.2%) versus 177.9±277.2 min (27.0±23.8%), difference −22.0% (95% CI −27.6–−16.4%); p<0.0001). Kaplan–Meier analysis depicted a significant difference in terms of hypoxaemia (p=0.01) and severe hypoxaemia (p=0.0003) occurrence between groups in favour of the automated group. 25 patients experienced hypoxaemia for >10% of the entire monitoring time during the 3 days within the standard group, as compared to the automated group (p<0.0001).Conclusion Automated closed-loop oxygen administration promotes greater time within the oxygenation target, as compared to standard manual administration, thus reducing the occurrence of hypoxaemia and hyperoxaemia.Following high-risk surgery, automated closed-loop oxygen administration promotes a higher time within range as compared to standard manual administration https://bit.ly/2ZPHT5Y ER -