ty -jour t1-强制振荡力学的日常变异性，用于早期检测COPD JF急性加重 - 欧洲呼吸杂志-Zimmermann，Sabine C. Au -Huvanandana，Jacqueline Au -Nguyen，Chinh D. Au -Bertolin，Amy Au -Watts，Joanna C. Au -Gobbi -Gobbi -Gobbi，Alessandro au -Farah -Farah，Claude S. Au -Peters，Matthew J.Au，Matthew J.Au，Matthew J.Au-Dellacà，Raffaele L. Au- King，Gregory G. Au -Thamrin，Cindy Y1-2020/09/01 Ur -http：//www.qdcxjkg.com/content.com/content/56/3/3/3/3/1901739.Abstrack N2-背景N2-背景telemonitoringing早期发现慢性阻塞性肺疾病（AECOPD）急性加重的试验提供了混合的结果。通过强制振荡技术（FOT）测量的肺功能的日常变化可能会产生更大的见解。我们评估了FOT度量可变异性的家庭远程监控的临床实用性，其中1）与症状和生活质量的关系（QOL）；2）FOT度量和症状变化的时机在AECOPD。COPD评估测试（CAT）和4周的QOL数据（St George的呼吸问卷（SGRQ））在8-9个月内记录了慢性阻塞性肺疾病（COPD）患者。R和X的可变性计算为7天运行窗口内的标准偏差（SD），我们还检查了窗口大小的效果。使用线性混合建模，FOT变异性的每日变化和AECOPD之前的CAT变化评估FOT与CAT和SGRQ的关系预测在39±10％的1 s（FEV1）的强迫呼气量的中位数（四分位数（IQR））依从性为95.4％（79.0–98.8％）。 Variability of the inspiratory component of X (indicated by the standard deviation of inspiratory reactance (SDXinsp)) related to CAT and weakly to SGRQ (fixed effect estimates 1.57, 95% CI 0.65–2.49 (p=0.001) and 4.41, 95% CI −0.06 to 8.89 (p=0.05), respectively). SDXinsp changed significantly on the same day as CAT (1 day before AECOPD, both p=0.02) and earlier when using shorter running windows (3 days before AECOPD, p=0.01; accuracy=0.72 for 5-day windows).Conclusions SDXinsp from FOT telemonitoring reflects COPD symptoms and may be a sensitive biomarker for early detection of AECOPD.Telemonitoring of day-to-day variations in lung function using oscillometry in COPD may help assess symptoms and detect acute exacerbations early https://bit.ly/2RUhn7c ER -