Ty-jour t1 - 肺外结节病的临床表型：法国，多种多联群组jf - 欧洲呼吸杂志jo - 欧元jo - 欧元jo do - 10.1183 / 13993003.01160-2020 sp - 2001160 au - lhote，raphael au - Annesi-Maesano，Isabella Au - Nunes，Hilario Au - Launay，David Au - Borie，Raphael Au - Sacré，尼古拉斯Au - Hamidou，Mohamed Au - Mahevas，Matthieu Au - Devilliers，HervéAu - Bonniaud，Philippe Au -LHOTE，FRANÇOISAU - Harche，Julien Au - Rufat，Pierre Au - Amoura，Zahir Au - Valeyre，Dominique Au - Cohen Aubart，Fleur Y1 - 2020 / 01/01 Ur - //www.qdcxjkg.com/content/早期/ 2020 / 08/13 / 13993003.01160-2020.Abstract n2 - 背景结节病是一种罕见的临床特征和结果中的异质性罕见疾病。我们旨在探讨结节病变表型及其特别注意肺外亚组的临床相关性。患者和方法患者EPISARC（结节病的流行病学）研究是法国回顾性多中心研究。根据标准化议定书，通过使用2013年和2016年在2013年和2016年间的11家医院中心的适当代码通过国家住院记录来确定结节病患者。审查了医疗图表。使用分层聚类分析定义了结节病的表型。结果总共包括1237名患者（562名男性和675名女性）。结节病的平均年龄诊断为43.5±13岁。等级簇分析根据器官受累和疾病类型和症状确定了五种不同的表型：1）（n = 180）红斑节细胞，关节受累和肝淋巴结;2）（n = 137）眼睛，神经系统，消化和肾受累;3）（n = 630）抗纤维化和心脏受累的肺部受累; 4) (n=41) lupus pernio and a high percentage of severe involvement; and 5) (n=249) hepatosplenic, peripheral lymph node and bone involvement. Phenotype 1 was associated with being European and female and with nonmanual work; phenotype 2 with being European; and phenotypes 3 and 5 with being non-European. The labor worker proportion was significantly lower in phenotype 5 than in the other phenotypes.Answer to the question This multicenter study confirms the existence of distinct phenotypes of sarcoidosis, with a nonrandom distribution of organ involvement. These phenotypes differ according to gender, geographical origin and socioprofessional categories.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Lhote has nothing to disclose.Conflict of interest: Dr. Annesi-Maesano has nothing to disclose.Conflict of interest: Dr. Nunes has nothing to disclose.Conflict of interest: Dr. Launay has nothing to disclose.Conflict of interest: Dr. Borie has nothing to disclose.Conflict of interest: Dr. Sacre has nothing to disclose.Conflict of interest: Dr. Schleinitz has nothing to disclose.Conflict of interest: Dr. Hamidou has nothing to disclose.Conflict of interest: Dr. Mahevas has nothing to disclose.Conflict of interest: Dr. Devilliers has nothing to disclose.Conflict of interest: Dr. Bonniaud has nothing to disclose.Conflict of interest: Dr. Lhote has nothing to disclose.Conflict of interest: Dr. Haroche has nothing to disclose.Conflict of interest: Dr. Rufat has nothing to disclose.Conflict of interest: Dr. Amoura has nothing to disclose.Conflict of interest: Dr. Valeyre has nothing to disclose.Conflict of interest: Dr. Cohen Aubart reports In addition, Dr. Cohen Aubart has a patent IL-6 antagonists as a treatment of sarcoidosis pending. ER -