％0期刊论文％A Turkovic，利迪％A Caudri，大安％A罗塞诺，添％A布鲁尔，乌迪德％A默里康纳尔％A Tiddens，危害A.W.M.％A Ramanauskas，菲奥娜％A兰加纳坦，萨拉C.％A霍尔，格雷厄姆L.％A棒，斯蒂芬·％A，在幼儿患有囊性纤维化％d 2020％R长期功能预后的％T结构性决定10.1183 / 13993003.00748-2019％Ĵ欧洲呼吸杂志％P 1900748％V 55％N 5％X背景加速肺功能在患有囊性纤维化的个体下降（CF）开始于青春期与呼吸系统并发症是在以后的生活死亡的最常见的原因。促进肺功能下降的因素还不是很清楚，在儿童早期结构性肺病特别是它的关系。Detection and management of structural lung disease could be an important step in improving outcomes in CF patients.Methods Annual chest computed tomography (CT) scans were available from 2005 to 2016 as a part of the AREST CF cohort for children aged 3 months to 6 years. Annual spirometry measurements were available for 89.77% of the cohort (167 children aged 5–6 years) from age 5 to 15 years through outpatient clinics at Perth Children's Hospital (Perth, Australia) and The Royal Children's Hospital in Melbourne (Melbourne, Australia) (697 measurements, mean±sd age 9.3±2.1 years).Results Children with a total CT score above the median at age 5–6 years were more likely to have abnormal forced expiratory volume in 1 s (FEV1) (adjusted hazard ratio 2.67 (1.06–6.72), p=0.037) during the next 10 years compared to those below the median chest CT score. The extent of all structural abnormalities except bronchial wall thickening were associated with lower FEV1 Z-scores. Mucus plugging and trapped air were the most predictive sub-score (adjusted mean change −0.17 (−0.26 – −0.07) p<0.001 and −0.09 (−0.14 – −0.04) p<0.001, respectively).Discussion Chest CT identifies children at an early age who have adverse long-term outcomes. The prevention of structural lung damage should be a goal of early intervention and can be usefully assessed with chest CT. In an era of therapeutics that might alter disease trajectories, chest CT could provide an early readout of likely long-term success.Structural lung changes identified on a chest CT scan in children with cystic fibrosis under 6 years of age can identify those at risk of adverse long-term outcomes http://bit.ly/39QH5jv %U //www.qdcxjkg.com/content/erj/55/5/1900748.full.pdf