TY - JOUR T1 -哮喘和吸烟与青少年和成年早期肺功能损害的相关性:怀特岛的出生队列研究摩根富林明-欧洲呼吸杂志》乔和J - 10.1183/13993003.00477 -2019欧元六世- 55 - 3 SP - 1900477 AU -艾尔沙德,s·哈桑盟——Hodgekiss克莱尔AU -霍洛威学院约翰w . AU - Kurukulaaratchy,拉梅什盟——Karmaus AU -张,右舵红煤AU -罗伯茨我们调查了从儿童到成年早期哮喘和吸烟与肺功能和气道可逆性的关系。以人群为基础的怀特岛出生队列(n=1456)分别在出生时、1、2、4、10、18和26岁时进行评估。哮喘被定义为医生诊断加上当前的喘息和/或治疗。肺活量测定分别在10岁(n=981)、18岁(n=839)和26岁(n=547)进行。根据26岁的哮喘和吸烟情况，将个体分为不吸烟的哮喘患者、不吸烟的哮喘患者、不吸烟的哮喘患者和吸烟的哮喘患者。使用纵向模型研究了他们10 - 26年的肺功能轨迹。不吸烟与哮喘有较小的用力呼气量在1 s (FEV1), fef25 - 75%(用力呼气流量在25 - 75%的用力肺活量(FVC))和FEV1 / FVC的比率比非吸烟者没有哮喘10岁和18年,后与差异减少支气管扩张剂(pre-bronchodilator FEV1在26年的3.75 L和4.02 L,术中;0.001;使用支气管扩张剂后4.02 L vs 4.16 L, p=0.08)。这种肺功能缺陷在18年后没有恶化。 Smokers without asthma had smaller FEF25–75% and FEV1/FVC ratio (but not FEV1) at 26 years compared to nonsmokers without asthma, with the deficit appearing after 18 years and persisting despite bronchodilator response (for FEV1/FVC ratio at 26 years 0.80 versus 0.81, p=0.002; post-bronchodilator 0.83 versus 0.85, p=0.005). Smokers with asthma had worse lung function compared to other groups.Lung function deficits associated with asthma and smoking occur early in life. They are not fully responsive to bronchodilators, indicating a risk for long-term lung health, which highlights the need to institute preventive measures in adolescence and early adult life before irreversible damage occurs.Asthma is associated with reduced lung function growth between 10 and 18 years; smoking is associated with decline between 18 and 26 years. Both may increase susceptibility to COPD, emphasising a potential benefit of intervention to prevent lung damage. http://bit.ly/33yPZyM ER -