首次临床表现的肺外结核的特征:横断面观察¹⁸F-FDG成像研究在六个国家摩根富林明欧洲呼吸杂志乔和J FD欧元欧洲呼吸学会SP 1901959 10.1183/13993003.01959 -2019签证官55 2 A1 Bom188bet官网地址anji,贾姆希A1沙玛,Rajnish A1米塔尔,Bhagwant r . A1 Gambhir Sanjay A1 Qureshy Ahmad A1的女王,、中频A1部门,戴安娜A1 Sathekge,迈克A1沃斯,Mariza A1 Sobic Saranovic, Dragana A1 Pusuwan, Pawana A1曼,维拉A1 Vinjamuri,索班A1 Zumla, Alimuddin A1帕斯卡,摘要背景:全球巨大的肺外结核(EPTB)病例负担中有很大一部分是经验治疗的，没有对疾病部位和多器官疾病累及程度的准确定义。摘要应用2-脱氧-2-(氟-18)氟-d-葡萄糖(18F-FDG)正电子发射断层显像(PET)在结核病诊断中的应用，是一种有效的疾病定位和疾病范围的显像技术。方法我们对印度、巴基斯坦、泰国、南非、塞尔维亚和孟加拉国等6个国家的8个中心的hiv阴性成人患者进行了一项新的临床诊断EPTB的研究，以评估首次发病时的疾病程度和常见部位。两周内进行18F-FDG PET/ CT扫描。结果358例EPTB患者(女189例;169名男性)被招募超过45个月，年龄范围18-83岁(女性平均30岁;男性平均38岁)。358名患者(183名女性，167名男性)中有350人(98%)的扫描结果为阳性。在350人当中，有118人(33.7%)有单一肺外病变，而在350人当中，有232人(66.3%)有多个肺外病变(器官)。淋巴结、骨骼、胸膜和大脑是常见的部位。 100 (28%) out of 358 EPTB patients had 18F-FDG PET/CT-positive sites in the lung. 110 patients were 18F-FDG PET/CT-positive in more body sites than were noted clinically at first presentation and 160 patients had the same number of positive body sites.Interpretation 18F-FDG PET/CT scan has potential for further elucidating the spectrum of disease, pathogenesis of EPTB and monitoring the effects of treatment on active lesions over time, and requires longitudinal cohort studies, twinned with biopsy and molecular studies.18F-FDG PET/CT can localise EPTB disease sites not clinically detected. It may serve a useful tool for research studies defining pathogenetic mechanisms and cure, relapse and recurrence. http://bit.ly/2CKSH9a