TY - JOUR T1 - 金黄色葡萄球菌及其诱导ige的肠毒素:当前知识JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01592 -2019欧元SP - 1901592 AU Bachert老人盟——亨伯特,马克•AU - Hanania尼古拉·a . AU -张奶奶AU -霍尔盖特,斯蒂芬盟——镶嵌细工,罗兰AU -代理,芭芭拉·m . Y1 - 2020/01/01 UR - //www.qdcxjkg.com/content/early/2020/01/03/13993003.01592 - 2019. -抽象N2 -虽然早发性免疫球蛋白E是一个杰出的生物标志物,其水平是经常在非过敏性哮喘晚发性升高。然而，IgE在后者中的表达模式多为多克隆，特异性IgEs水平较低或低于检测水平，但总IgE水平升高。在迟发性重症哮喘患者中，血清中可检测到葡萄球菌肠毒素特异性IgE (se-IgE)，并与哮喘相关，以住院、口服类固醇和肺功能下降为特征的重症哮喘。最近，se-IgE甚至被证明可以预测未来十年严重哮喘的发展。金黄色葡萄球菌通过其蛋白，包括超抗原、丝氨酸蛋白样蛋白(spls)或蛋白A (SpA)等，在不同程度上操纵气道粘膜免疫。IL-33从呼吸道上皮细胞中释放，先天淋巴样细胞(ILCs)通过其受体ST2激活，2型细胞因子从这些ILCs和TH2细胞中释放，肥大细胞脱颗粒，大量局部b细胞激活和IgE形成，最后是嗜酸性粒细胞吸引，随之释放细胞外陷阱，金黄色葡萄球菌操纵粘膜免疫最显著的特征是通过形成Charcot-Leyden晶体增加上皮损伤并使疾病持续。综上所述，金黄色葡萄球菌在严重气道炎症和当前及未来疾病严重程度的调控中起着重要作用。在这篇综述中，我们讨论了这一领域的现有知识，并概述了未来研究的需要，以充分了解金黄色葡萄球菌及其蛋白对哮喘的影响。该手稿最近已被《欧洲呼吸杂志》接受发表。 It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Bachert has nothing to disclose.Conflict of interest: Dr. Humbert reports personal fees from Astrazeneca, personal fees from GSK, personal fees from Merck, personal fees from Novartis, personal fees from Roche, personal fees from Sanofi, personal fees from Teva, outside the submitted work.Conflict of interest: NAH has received honoraria for serving on advisory boards or as consultant from Novartis, Genentech, Roche, Novartis, AstraZeneca, GSK, Gossamer Bio and Boehringer Ingelheim. His institution received research grant support on his behalf from GSK, Boehringer Ingelheim, AstraZenecaConflict of interest: Dr. Zhang has nothing to disclose.Conflict of interest: Dr. holgate has nothing to disclose.Conflict of interest: Dr. Buhl has nothing to disclose.Conflict of interest: Dr. Bröker has nothing to disclose. ER -