电子T1端粒lengt RT老杂志文章h and genetic variant associations with interstitial lung disease progression and survival JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1801641 DO 10.1183/13993003.01641-2018 VO 53 IS 4 A1 Newton, Chad A. A1 Oldham, Justin M. A1 Ley, Brett A1 Anand, Vikram A1 Adegunsoye, Ayodeji A1 Liu, Gabrielle A1 Batra, Kiran A1 Torrealba, Jose A1 Kozlitina, Julia A1 Glazer, Craig A1 Strek, Mary E. A1 Wolters, Paul J. A1 Noth, Imre A1 Garcia, Christine Kim YR 2019 UL //www.qdcxjkg.com/content/53/4/1801641.abstract AB Leukocyte telomere length (LTL), MUC5B rs35705950 and TOLLIP rs5743890 have been associated with idiopathic pulmonary fibrosis (IPF).In this observational cohort study, we assessed the associations between these genomic markers and outcomes of survival and rate of disease progression in patients with interstitial pneumonia with autoimmune features (IPAF, n=250) and connective tissue disease-associated interstitial lung disease (CTD-ILD, n=248). IPF (n=499) was used as a comparator.The LTL of IPAF and CTD-ILD patients (mean age-adjusted log-transformed T/S of −0.05±0.29 and −0.04±0.25, respectively) is longer than that of IPF patients (−0.17±0.32). For IPAF patients, LTL <10th percentile is associated with faster lung function decline compared to LTL ≥10th percentile (−6.43% per year versus −0.86% per year; p<0.0001) and worse transplant-free survival (hazard ratio 2.97, 95% CI 1.70–5.20; p=0.00014). The MUC5B rs35705950 minor allele frequency (MAF) is greater for IPAF patients (23.2, 95% CI 18.8–28.2; p<0.0001) than controls and is associated with worse transplant-free IPAF survival (hazard ratio 1.92, 95% CI 1.18–3.13; p=0.0091). Rheumatoid arthritis (RA)-associated ILD (RA-ILD) has a shorter LTL than non-RA CTD-ILD (−0.14±0.27 versus −0.01±0.23; p=0.00055) and higher MUC5B MAF (34.6, 95% CI 24.4–46.3 versus 14.1, 95% CI 9.8–20.0; p=0.00025). Neither LTL nor MUC5B are associated with transplant-free CTD-ILD survival.LTL and MUC5B MAF have different associations with lung function progression and survival for IPAF and CTD-ILD.Leukocyte telomere length and MUC5B minor allele frequency are similar for IPAF and the combined CTD-ILD group; however, the associations between these genomic markers and clinical outcomes are different for these two types of ILD http://ow.ly/wXem30njRkg