抽象
结节病有关的死亡率出现在北美地区不断上升,在女性和老年人的增加速率。我们的目的是评估在安大略省,加拿大结节病发病率,患病率和死亡率的趋势。
我们使用卫生行政数据的队列研究,从1996年安大略省 - 2015年国际疾病分类和安大略省健康保险计划之间的代码被用于案件侦破。Three disease definitions were created: 1) sarcoidosis, two or more physician claims within 2 years; 2) chronic sarcoidosis, five or more physician claims within 3 years; and 3) sarcoidosis with histology, two or more physician claims with a tissue biopsy performed between claims.
Overall, 18 550, 9199 and 3819 individuals with sarcoidosis, chronic sarcoidosis and sarcoidosis with histology, respectively, were identified. The prevalence of sarcoidosis was 143 per 100 000 in 2015, increasing by 116% (p<0.0001) from 1996. The increase in age-adjusted prevalence was higher in males than females (136%与99%;P <0.0001)。The incidence of sarcoidosis declined from 7.9 to 6.8 per 100 000 between 1996 and 2014 (15% decrease; p=0.0009). A 30.3% decrease in incidence was seen among females (p<0.0001) compared with a 5.5% increase in males (p=0.47). Age- and sex-adjusted mortality rates of patients with sarcoidosis rose from 1.15% to 1.47% between 1996 and 2015 (28% increase; p=0.02), with the overall trend being nonsignificant (p=0.39). Mortality rates in patients with chronic sarcoidosis increased significantly over the study period (p=0.0008).
结节病的患病率正在上升在安大略省,与疾病负担的表观移位趋势从女性对男性。死亡率在慢性结节增大。
抽象
The prevalence of sarcoidosis in Canada is increasing, with an estimated rate of 143 per 100 000 as of 2015. The burden of sarcoidosis is changing, with increasing incidence among males in recent years and decreasing disease rates in females.http://bit.ly/2K4WxP5
脚注
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作者投稿:L.M.菲德勒,M.巴尔特,J.H.费舍尔,M.B。Stanbrook和A.革顺促成了进行研究的构思和设计。L.M.菲德勒,T.要和A.革顺参与了数据分析。所有作者负责数据解释,起草的手稿,并最终版本的批准。
利益冲突:L.M。菲德勒有没有透露。
利益冲突:M.巴尔特有没有透露。
利益冲突:J.H。费舍尔没有透露。
利益冲突:T.为了有没有透露。
利益冲突:M.B。Stanbrook有没有透露。
利益冲突:A.革顺有没有透露。
支持声明:此研究是由患者的捐赠来源的西奈山医院的研究基金资助。本文资金的信息已交存交叉引用出资者注册。
- 收到2019年3月2日。
- 公认2019年7月24日。
- 版权所有©ERS 2019
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