RT杂志文章SR电子T1普遍卫生保健人群中结节病的流行病学和健康结局:一项队列研究JF欧洲呼吸杂志JO Eur Respir J FD欧洲呼吸学会SP 1900444 DO 10.1183/139930188bet官网地址03.00444-2019 VO 54 IS 4 A1 Fidler, Lee M. A1 Balter, Meyer A1 Fisher, Jolene H. A1 To, Teresa A1 Stanbrook, Matthew B. A1 Gershon, Andrea YR 2019 UL //www.qdcxjkg.com/content/54/4/1900444.abstract AB结节病相关死亡率在北美似乎正在上升，女性和老年人的死亡率正在上升。我们旨在估计加拿大安大略省结节病发病率、患病率和死亡率的趋势。我们使用1996年至2015年安大略省的卫生行政数据进行了一项队列研究。使用国际疾病分类和安大略省健康保险计划代码进行病例发现。创建了三种疾病定义:1)结节病，2年内2例或2例以上的医生索赔;2)慢性结节病，3年内5次及以上医生索赔;3)组织学结节病，两次或两次以上的医生索赔之间进行组织活检。总的来说，分别有18550例、9199例和3819例结节病、慢性结节病和有组织学的结节病被确诊。2015年结节病患病率为143 / 10万，比1996年增加了116% (p<0.0001)。男性年龄调整患病率的增长高于女性(136%对99%; p<0.0001). The incidence of sarcoidosis declined from 7.9 to 6.8 per 100 000 between 1996 and 2014 (15% decrease; p=0.0009). A 30.3% decrease in incidence was seen among females (p<0.0001) compared with a 5.5% increase in males (p=0.47). Age- and sex-adjusted mortality rates of patients with sarcoidosis rose from 1.15% to 1.47% between 1996 and 2015 (28% increase; p=0.02), with the overall trend being nonsignificant (p=0.39). Mortality rates in patients with chronic sarcoidosis increased significantly over the study period (p=0.0008).The prevalence of sarcoidosis is rising in Ontario, with an apparent shifting trend in disease burden from females to males. Mortality is increasing in patients with chronic sarcoidosis.The prevalence of sarcoidosis in Canada is increasing, with an estimated rate of 143 per 100 000 as of 2015. The burden of sarcoidosis is changing, with increasing incidence among males in recent years and decreasing disease rates in females. http://bit.ly/2K4WxP5