抽象
人冠状病毒(冠状病毒)占普通感冒的15-30%,但只有一个病例报告已经描述了冠状病毒感染的效果,这是无症状的,对人体呼吸道上皮。
作者检查感染的冠状病毒的纤毛的结构和功能在通过鼻内接种冠状病毒感染229E健康志愿者的影响。另有4名志愿者假感染紫外线灭活病毒。Immediately before inoculation (day 0) and 3 days later (day 3), ciliated epithelium was obtained by brushing the inferior nasal turbinate. Ciliary beat frequency was determined and beat pattern analysed for evidence of dyskinesia (0=normal, 3=severely dyskinetic) using digital high-speed video photography. Ciliary ultrastructure was examined by transmission electron microscopy. Symptom diaries were kept for the duration of the study.
All subjects inoculated with HCoV, including the three who did not develop symptoms of an upper respiratory tract infection, had disruption of their respiratory epithelium on day 3. Although there was no difference in the mean ciliary beat frequency between day 0 (11.3 Hz (95% confidence interval (CI): 8.6–14.0) and day 3 (9.4 Hz (95% CI 7.2–11.6)), there was a significant increase (p<0.05) in the ciliary dyskinesia score between day 0 (0.2 (95% CI 0–0.5)) and day 3 (1.1 (95% CI 0.5–1.7). In sham-infected subjects, no differences in epithelial integrity, or ciliary structure and function were found between day 0 and day 3.
与纤毛上皮和纤毛运动障碍的人冠状病毒造成的破坏健康志愿者接种。这可能是损害纤毛清除。损害呼吸道上皮,由于人类冠状病毒感染,可能没有明显的临床症状出现。
这项工作是由囊性纤维化信托,泥瓦匠医学基金会和国家哮喘运动的支持。
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