@article {Chilvers965，作者= {Chilvers，M.A。和麦基恩，M。和Rutman，A。和敏，B.S.和西尔弗曼，M.和O {\ textquoteright}卡拉汉，C.}，标题= {的人类冠状病毒的影响鼻纤毛呼吸道上皮}，体积= {18}，数= {6}，页= {965--970}，年= {} 2001，DOI = {10.1183 / 09031936.01.00093001}，出版商= {欧洲呼吸学会}，抽象=188bet官网地址 {人类冠状病毒（冠状病毒）占15 {\ textendash}感冒的30 \％，但只有一个病例报告已经描述了冠状病毒感染的效果，这是无症状的，对人体呼吸道上皮。作者检查感染的冠状病毒的纤毛的结构和功能在通过鼻内接种冠状病毒感染229E健康志愿者的影响。另有4名志愿者假感染紫外线灭活病毒。立即接种前（第0天）和3天后（第3天），用刷涂下鼻甲骨获得纤毛上皮。纤毛运动频率测定和拍频波形图使用数字高速视频照相分析的运动障碍（0 =正常，3 =严重运动障碍）的证据。睫状超微结构通过透射电子显微镜检查。症状日记被保存在研究期间。 All subjects inoculated with HCoV, including the three who did not develop symptoms of an upper respiratory tract infection, had disruption of their respiratory epithelium on day 3. Although there was no difference in the mean ciliary beat frequency between day 0 (11.3 Hz (95\% confidence interval (CI): 8.6{\textendash}14.0) and day 3 (9.4 Hz (95\% CI 7.2{\textendash}11.6)), there was a significant increase (p\<0.05) in the ciliary dyskinesia score between day 0 (0.2 (95\% CI 0{\textendash}0.5)) and day 3 (1.1 (95\% CI 0.5{\textendash}1.7). In sham-infected subjects, no differences in epithelial integrity, or ciliary structure and function were found between day 0 and day 3. Inoculation of healthy volunteers with human coronavirus caused disruption of the ciliated epithelium and ciliary dyskinesia. This is likely to impair mucociliary clearance. Damage to the respiratory epithelium, due to human coronavirus infection, may occur without overt clinical symptoms. This work was supported by The Cystic Fibrosis Trust, Masons Medical Foundation and The National Asthma Campaign.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/18/6/965}, eprint = {//www.qdcxjkg.com/content/18/6/965.full.pdf}, journal = {European Respiratory Journal} }