TY - T1的冠状病毒对人类的影响鼻腔呼吸道上皮细胞纤毛JF -欧洲呼吸杂志》乔欧元和J SP - 965 LP - 970 - 10.1183 / 09031936.01.00093001六世——18 - 6盟Chilvers硕士非盟-麦克基恩,m . AU - Rutman a . AU -敏,狗屁AU -西尔弗曼,m . AU -奥卡拉汉C. Y1 - 2001/12/01 UR - //www.qdcxjkg.com/content/18/6/965.abstract N2 -人类冠状病毒(HCoV)占普通感冒的15-30%，但只有一个病例报告描述了无症状冠状病毒感染对人类呼吸道上皮的影响。作者研究了鼻内接种HCoV 229E感染的健康志愿者感染HCoV对睫状体结构和功能的影响。另外四名志愿者假装感染了紫外线灭活病毒。接种前(第0天)和接种后3天(第3天)，刷拭下鼻甲获得纤毛上皮。使用数字高速视频摄影确定睫状搏动频率并分析搏动模式是否存在运动障碍(0=正常，3=严重运动障碍)。透射电镜观察纤毛超微结构。在研究期间记录症状日记。所有接种HCoV的受试者，包括3名没有出现上呼吸道感染症状的受试者，在第3天发生了呼吸道上皮破坏。虽然没有差别意味着纤毛第0天之间的拍频(11.3赫兹(95%可信区间(CI): 8.6 - -14.0)和第三天(9.4赫兹(95% CI 7.2 - -11.6),有显著增加(术中;0.05)之间的纤毛运动障碍得分0天(0.2 (95% CI 0 - 0.5)),第三天(1.1 (95% CI 0.5 - -1.7)。 In sham-infected subjects, no differences in epithelial integrity, or ciliary structure and function were found between day 0 and day 3. Inoculation of healthy volunteers with human coronavirus caused disruption of the ciliated epithelium and ciliary dyskinesia. This is likely to impair mucociliary clearance. Damage to the respiratory epithelium, due to human coronavirus infection, may occur without overt clinical symptoms. This work was supported by The Cystic Fibrosis Trust, Masons Medical Foundation and The National Asthma Campaign. ER -