抽象
病毒性呼吸道感染有牵连为慢性阻塞性肺疾病(AECOPD)急性发作的主要危险因素。我们的目的是评估,纵向,由病毒和AECOPD上呼吸道感染(URTI)之间的关联。
Detection of 18 viruses was performed in naso- and orοpharyngeal swabs from 450 COPD patients (Global Initiative for Chronic Obstructive Lung Disease stages 2–4) who were followed for a mean of 27 months. Swabs were taken during stable periods (n=1909), at URTI onset (n=391), 10 days after the URTI (n=356) and during an AECOPD (n=177) and tested using a multiplex nucleic acid amplification test.
Evidence of at least one respiratory virus was significantly higher at URTI onset (52.7%), 10 days after the URTI (15.2%) and during an AECOPD (38.4%), compared with the stable period (5.3%, p<0.001). During stable visits, rhinovirus accounted for 54.2% of all viral infections, followed by coronavirus (20.5%). None of the viruses were identified in two consecutive stable visits. Patients with a viral infection at URTI onset did not have a higher incidence of exacerbation than patients without viral infection (p=0.993). Τhe incidence of any viral infection during an AECOPD was similar between URTI-related AECOPD and non-URTI-related AECOPD (p=0.359). Only 24% of the patients that had a URTI-related AECOPD had the same virus at URTI onset and during an AECOPD. Detection of parainfluenza 3 at URTI onset was associated with a higher risk of an AECOPD (p=0.003). Rhinovirus and coronavirus were the most frequently detected viruses during AECOPD visits, accounting for 35.7% and 25.9% of all viral infections, respectively.
病毒感染的过程中COPD稳定期发病率是很低的。发作的上呼吸道感染症状发作后的风险取决于与该事件相关联的特定病毒只为副流感3显著。
抽象
病毒在患者中存在稳定COPD是罕见的。上呼吸道感染的病毒没有本身有恶化的风险增加有关。URTI与生命和肺功能恶化独立的质量恶化相关联。http://bit.ly/30jGm5N
脚注
这篇文章有提供补充材料www.qdcxjkg.com
作者投稿:D.斯托尔兹,H.H.赫希和M.塔姆构思和设计研究。D.斯托尔兹,D. Schilter,R.路易,E. PAPAKONSTANTINOU,M.塔姆和W.斯特罗贝尔收集的患者数据。赫希H.H.组织和监督的呼吸道病毒病原的多重分子诊断测试。C.辛德勒和L. Grize进行的统计分析。所有作者促成并同意最终的文本,以从开始工作,直到出版的完整性全部责任。
利益冲突:D.斯托尔兹有没有透露。
利益冲突:E. PAPAKONSTANTINOU有没有透露。
利益冲突:L. Grize有没有透露。
利益冲突:D. Schilter有没有透露。
利益冲突:W.斯特罗贝尔有没有透露。
利益冲突:R.路易斯有没有透露。
利益冲突:C.辛德勒有没有透露。
利益冲突:H.H.赫希有没有透露。
利益冲突:M.塔姆有没有透露。
支持声明:本研究报告分析了PREVENT研究,主要是由瑞士国家基金会授予#PP00-P3_128412 / 1 D.斯托尔兹和肺病的临床资助的研究者发起和推动研究的共同主要终点的巴塞尔大学医院和生物医学系,瑞士巴塞尔大学。雅特AG捐款,赠款不受限制。通讯作者有权在研究中完全访问所有数据,并曾经为决定递交出版负有最终责任。本文资金的信息已交存交叉引用出资者注册。
- 收到2019年2月27日。
- 公认2019年6月28日。
- 版权所有©ERS 2019
中个体
登录使用您的用户名和密码
图书馆用户
通过您的机构登录
购买访问
联系我们
如果您对ERS出版物的网站有任何疑问,请联系journals@ersnet.org