TY - T1的时间进程的上呼吸道病毒感染和慢性阻塞性肺病恶化JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00407 -2019欧元六世- 54 - 4 SP - 1900407 AU Stolz Daiana盟——Papakonstantinou Eleni盟——Grize Leticia盟——Schilter丹尼尔盟,Strobel Werner AU -路易斯,Renaud盟——辛德勒,基督教非盟-赫希,汉斯·h . AU -塔姆,迈克尔Y1 - 2019/10/01 UR - //www.qdcxjkg.com/content/54/4/1900407.abstract N2 -牵扯病毒性呼吸道感染的主要危险因素为慢性阻塞性肺疾病急性加重(AECOPD)。我们旨在评估,纵向,上呼吸道感染之间的联系(URTI)由病毒引起,AECOPD。18检测病毒naso -执行和orοpharyngeal拭子从450名慢性阻塞性肺病患者(慢性阻塞性肺疾病的全球倡议阶段2 - 4)一直跟踪了27个月的意思。拭子被稳定的时期(n = 1909),在URTI发作(n = 391), 10天后URTI (n = 356)和在AECOPD (n = 177)使用复合核酸扩增试验和测试。至少一个呼吸道病毒的证据在URTI发作(52.7%),明显高于10天后URTI(15.2%)和在AECOPD(38.4%),而稳定的时期(5.3%,术中;0.001)。稳定的访问期间,鼻病毒所有病毒感染的占54.2%,其次是冠状病毒(20.5%)。没有病毒被发现在两个连续稳定的访问。病毒感染患者在发病URTI没有恶化发生率高于病人没有病毒感染(p = 0.993)。Τhe任何病毒感染的发生率在AECOPD之间类似URTI-related AECOPD和non-URTI-related AECOPD (p = 0.359)。只有24%的病人有URTI-related AECOPD有同样的病毒在AECOPD URTI发病和。 Detection of parainfluenza 3 at URTI onset was associated with a higher risk of an AECOPD (p=0.003). Rhinovirus and coronavirus were the most frequently detected viruses during AECOPD visits, accounting for 35.7% and 25.9% of all viral infections, respectively.The prevalence of viral infection during the stable period of COPD was low. The risk of exacerbation following the onset of URTI symptoms depends on the particular virus associated with the event and was significant only for parainfluenza 3.The presence of viruses in patients with stable COPD is rare. URTI viruses were not per se associated with an increased risk of exacerbation. URTI is associated with worsening of quality of life and lung function independently of exacerbation. http://bit.ly/30jGm5N ER -