Abstract
IntroductionThe beneficial effect of improving air quality on lung function in the elderly remains unclear. We examined associations between decline in air pollutants and lung function, and effect modifications by genetics and body mass index (BMI), in elderly German women.
Methods从未来的唾液(斯图数据进行分析dy on the influence of Air pollution on Lung function, Inflammation and Aging) study (n=601). Spirometry was conducted at baseline (1985–1994; age 55 years), in 2007–2010 and in 2012–2013. Air pollution concentrations at home addresses were determined for each time-point using land-use regression models. Global Lung Initiative 2012 z-scores were calculated. Weighted genetic risk scores (GRSs) were determined from lung function-related risk alleles and used to investigate interactions with improved air quality. Multiple linear mixed models were fitted.
ResultsAir pollution levels decreased substantially during the study period. Reduction of air pollution was associated with an increase in z-scores for forced expiratory volume in 1 s (FEV1) and the FEV1/forced vital capacity ratio. For a decrease of 10 µg·m−3in nitrogen dioxide (NO2), the z-score for FEV1increased by 0.14 (95% CI 0.01–0.26). However, with an increasing number of lung function-related risk alleles, the benefit from improved air quality decreased (GRS×NO2interaction: p=0.029). Interactions with BMI were not significant.
ConclusionsReduction of air pollution is associated with a relative improvement of lung function in elderly women, but also depends on their genetic make-up.
Abstract
Improvement of air pollution has a beneficial effect on lung function in elderly women. In the elderly, these beneficial effects of improved air quality also depend on a person's genetic make-up, but not upon obesity.http://ow.ly/3gjU30nxHB1
Footnotes
This article has supplementary material available fromwww.qdcxjkg.com
Author contributions: U. Krämer, T. Schikowski and B. Hoffmann were engaged in the study design of the SALIA study. A. Hüls, U. Krämer, K. Ickstadt and T. Schikowski planned the analyses. A. Hüls, D. Sugiri and H. Schwender prepared and/or analysed the data. A. Hüls was the major contributor in writing the manuscript. A. Hüls, D. Sugiri, M.J. Abramson, B. Hoffmann, H. Schwender, K. Ickstadt, U. Krämer and T. Schikowski revised the manuscript for important intellectual content and approved the final manuscript.
Conflict of interest: D. Hüls has nothing to disclose.
Conflict of interest: D. Sugiri has nothing to disclose.
Conflict of interest: M.J. Abramson reports grants from Pfizer, grants from Boehringer Ingelheim, assistance with conference attendance and honoraria for consultancy from Sanofi, outside the submitted work.
Conflict of interest: B. Hoffmann has nothing to disclose.
Conflict of interest: H. Schwender has nothing to disclose.
Conflict of interest: K. Ickstadt has nothing to disclose.
Conflict of interest: U. Krämer has nothing to disclose.
Conflict of interest: T. Schikowski has nothing to disclose.
Support statement: A. Hüls received a research fellowship from the Prof. Dr Dieter Platt foundation of the German Association for Aging Research (DGfA) for conducting this project. The SALIA cohort study was supported by the Deutsche Forschungsgemeinschaft (DFG; HE-4510/2-1, KR 1938/3-1, LU 691/4-1 and SCHI 1358/3-1), the Ministry of the Environment of the state of North Rhine-Westphalia (Düsseldorf, Germany), the Federal Ministry of the Environment (Berlin, Germany), DGUV (German Statutory Accident Assurance) VT 266.1, the European Community's Seventh Framework Programme (FP7/2007–2011) under grant agreement number 211250, the German Federal Ministry of Education and Research (BMBF), and the Research Commission of the Medical Faculty of the Heinrich Heine University of Düsseldorf (FoKo 9772465). The funders had no role in the study design, data collection and analysis, decision to publish or preparation of manuscript.
- ReceivedSeptember 18, 2018.
- AcceptedJanuary 27, 2019.
- Copyright ©ERS 2019
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