抽象的
Information on the clinical traits associated with bronchial neutrophilia in asthma is scant, preventing its recognition and adequate treatment. We aimed to assess the clinical, functional and biological features of neutrophilic asthma and identify possible predictors of bronchial neutrophilia.
基于支气管层的嗜酸性/嗜中性粒细胞计数,研究了70名温和至重度哮喘患者的炎症表型。患者被归类为嗜中性粒细胞或非嗜性嗜性。嗜中性哮喘患者(中性粒细胞计数截止:47.17中性粒细胞·mm−2; range: 47.17–198.11 neutrophils·mm−2; median: 94.34 neutrophils·mm−2) were further classified as high (≥94.34 neutrophils·mm−2) or intermediate (47.17– <94.34 neutrophils·mm−2). The effect of smoking ≥10 pack-years was also assessed.
Neutrophilic asthma patients (n=38; 36 mixed eosinophilic/neutrophilic) had greater disease severity, functional residual capacity, inhaled corticosteroid (ICS) dose and exacerbations, and lower forced vital capacity (FVC) % pred and forced expiratory volume in 1 s (FEV1)可逆性比非无营养性哮喘患者(n = 32; 28嗜酸性粒细胞和四个pacigranulocytic)。嗜中性哮喘患者的嗜酸性粒细胞计数相似,支气管CD8增加+, interleukin (IL)-17-F+and IL-22+cells, and decreased mast cells compared with non-neutrophilic asthma patients. FEV1and FVC reversibility were independent predictors of bronchial neutrophilia in our cohort. High neutrophilic patients (n=21) had increased serum IgE levels, sensitivity to perennial allergens, exacerbation rate, oral corticosteroid dependence, and CD4+和IL-17F+cells in their bronchial mucosa. Excluding smokers revealed increased IL-17A+and IL-22+cells in highly neutrophilic patients.
我们提供了新的证据,将哮喘中高支气管中性粒细胞的存在与与过敏(IGE)和IL-17/22细胞因子表达相关的适应性免疫反应联系起来。高支气管中性粒细胞可能会区分哮喘的新内型。关于支气管可逆性与支气管中性粒细胞的关系,需要进一步研究。
抽象的
具有高支气管中性粒细胞性的哮喘与血清IgE,多年生过敏和IL-17表达的增加有关+细胞。这种新的内型在临床上与上一年的加重率和OCS依赖性相关。http://bit.ly/2ZqboJ2
脚注
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支持声明:这项研究得到了Ricerca Sanitaria finalizzata地区Piemonte(2007年2472/2007和38097/2008)的支持。本文的资金信息已存入Crossref Funder Registry.
Conflict of interest: V. Carriero has nothing to disclose.
利益冲突:F。Bertolini无需披露。
Conflict of interest: A. Folino has nothing to disclose.
Conflict of interest: A. Mannelli has nothing to disclose.
Conflict of interest: A. Di Stefano has nothing to disclose.
Conflict of interest: I. Gnemmi has nothing to disclose.
Conflict of interest: R. Torchio has nothing to disclose.
Conflict of interest: F.L.M. Ricciardolo has nothing to disclose.
Conflict of interest: M. Bullone has nothing to disclose.
- 已收到2019年1月10日。
- AcceptedJuly 29, 2019.
- 版权所有©ERS 2019