Abstract
We evaluated the influence of untreated obstructive sleep apnoea (OSA) on the magnitude of cognitive decline and on several cognitive subdomains in patients with mild-to-moderate Alzheimer's disease.
In this single-centre study, 144 patients were recruited prospectively from a cognitive impairment unit and underwent overnight polysomnography.
The mean±sd change in the Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-cog) score at 12 months was 3.19±5.61 in the non-OSA group and 0.08±5.62 in the OSA group, with an intergroup difference of −3.36 (95% CI 0.19–0.16; p=0.002). We did not observe a significant difference in any cognitive subdomains at 12 months. Regarding Mini-Mental State Examination scores at 36 months, the mean change was 1.69 (95% CI −1.26–4.64; p=0.445). No significant differences were found among different OSA severity groups.
We observed that ADAS-cog scores were better in the OSA group than in the non-OSA group by a statistically but not clinically significant margin. We did not find differences in the different cognitive subdomains after 1 year or in global cognition after 3 years of follow-up.
Abstract
Untreated OSA did not decrease the cognitive evolution of a population with mild and moderate Alzheimer's disease https://bit.ly/3e55zYH
Footnotes
This article has supplementary material available from erj.ersjournals.com
This study is registered as a clinical trial: NCT02814045. Additional data from NCT02814045 will be shared by request from any qualified investigator.
Author contributions: I.D. Benítez, G. Torres, G. Piñol-Ripoll, F. Barbé and M. Sánchez-de-la-Torre designed the study. C. Jorge, A. Targa and M. Pujol searched the literature. C. Jorge, R. Huerto, O. Minguez, A. Gibert and M. Pujol collected the data. I.D. Benítez and A. Targa analysed the data. R. Farré, F. Barbé, G. Piñol-Ripoll, A. Targa and C. Jorge interpreted the data. C. Jorge, A. Targa and G. Piñol-Ripoll wrote the manuscript draft. All authors revised the manuscript and approved it for submission.
Conflict of interest: C. Jorge has nothing to disclose.
Conflict of interest: A. Targa has nothing to disclose.
Conflict of interest: I.D. Benítez has nothing to disclose.
Conflict of interest: F. Dakterzada has nothing to disclose.
Conflict of interest: G. Torres has nothing to disclose.
Conflict of interest: O. Minguez has nothing to disclose.
Conflict of interest: A. Carnes has nothing to disclose.
Conflict of interest: M. Pujol has nothing to disclose.
Conflict of interest: A. Gibert has nothing to disclose.
Conflict of interest: R. López has nothing to disclose.
Conflict of interest: A.M. Gaeta has nothing to disclose.
Conflict of interest: M. Dalmases has nothing to disclose.
Conflict of interest: R. Farré has nothing to disclose.
Conflict of interest: M. Sánchez-de-la-Torre has nothing to disclose.
Conflict of interest: F. Barbé has nothing to disclose.
Conflict of interest: G. Piñol-Ripoll has nothing to disclose.
Support statement: This work was supported by “Fundació La Marató TV3” (to G. Piñol-Ripoll), the Spanish Respiratory Society (SEPAR), PERIS SLT008/18/00050, the Health Department of Generalitat de Catalunya, ALLER, IRBLleida Biobank (B.0000682) and PLATAFORMA BIOBANCOS PT17/0015/0027. Funding information for this article has been deposited with the Crossref Funder Registry.
- Received March 5, 2020.
- Accepted June 9, 2020.
- Copyright ©ERS 2020