抽象的
Child maltreatment is associated with asthma in adults. We examined whether lifetime major depressive disorder (MDD) or lifetime generalised anxiety disorder (GAD) mediate an association between child maltreatment and current asthma among 81 105 British adults in the UK Biobank who completed a mental health survey and had complete data on child maltreatment, GAD, MDD, asthma, and relevant covariates but no diagnosis of chronic obstructive pulmonary disease. Child maltreatment was ascertained based on answers to the five questions in the Childhood Trauma Screener. Two mediators, lifetime MDD and GAD, were assessed based on the Composite International Diagnostic Interview Short Form (CIDI-SF). Current asthma was defined as physician-diagnosed asthma and wheeze or whistling in the chest in the previous year. Logistic regression was used for the multivariable analysis of child maltreatment and current asthma, and a mediation analysis was conducted to estimate the contributions of lifetime MDD and lifetime GAD to the child maltreatment-current asthma association. In a multivariable analysis, any child maltreatment was associated with asthma (adjusted odds ratio [aOR]=1.22, 95% confidence interval [CI]=1.15 to 1.28, p<0.01). In a mediation analysis adjusted for household income, educational attainment, smoking status, pack-years of smoking, and other covariates, lifetime GAD and lifetime MDD explained 21.8% and 32.5%, respectively, of the child maltreatment-current asthma association. Similar results were obtained after excluding current smokers and former smokers with ≥10 pack-years of smoking from the mediation analysis. Our findings suggest that GAD and MDD mediate an association between child maltreatment and asthma in adults, independently of smoking.
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利益冲突:Celedón博士从GSK和MERCK(吸入类固醇)和Pharmavite(维生素D和安慰剂胶囊)那里获得了研究材料,为NIH资助的研究中的参与者免费提供了与这项工作无关的参与者的药物。其他作者没有宣布的利益冲突。
- 已收到2021年12月14日。
- 公认2022年3月5日。
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