抽象
缩短的组胺激发试验是在职业气道疾病的研究中使用。我们评估安全性,定义为没有在用力呼气容积的大于40%一秒(FEV1)的降低。投诉的发生,测试结果的可重复性,和已保存的时间的平均量进行测定。的标准协议,使用包含30 s的顺序加倍浓度潮式呼吸从1到32 mg.ml-1组胺。没有指示气道高反应性的受试者开始在4 mg.ml-1。如果在FEV1的减少<6%,浓缩步骤被跳过(在浓度增加四倍)。当在FEV1的减少至少18%的测试被终止。共有697名受试者进行的测试。所有受试者与组胺在生产中的最低浓度开始FEV1(PC20)值<或= 4 mg.ml-1(N = 16)20%的降低的激发浓度。六名受试者达到>或= 20%FEV1在浓度增加四倍后减少(21-24范围%)。 Five subjects had a decrease in FEV1 of greater than 40%, and this decrease occurred after a doubling concentration. Cough, flushing, and chest tightness were noted in 18% of the subjects. In 56% of the tested subjects, the shortest provocation scheme (phosphate solution followed by 4, 16 and 32 mg.ml-1 histamine) was applied, resulting in a time reduction of nearly 50% per test, and reducing the time needed to complete the study from 5 to 3 months. The shortened test was repeatable within one concentration difference.(ABSTRACT TRUNCATED AT 250 WORDS)