PT -期刊文章盟克雷默盟——朋友,TM AU -欧登泽尔曾M盟——Kerkhof M AU - de Monchy詹盟——Rijcken B TI -缩短组胺的使用和安全挑战测试一个职业研究援助- 10.1183 / 09031936.95.08050737 DP - 1995年5月01 TA -欧洲呼吸杂志》第六PG - 737 - 741 - 8的IP - 5 4099 - //www.qdcxjkg.com/content/8/5/737.short 4100 - //www.qdcxjkg.com/content/8/5/737.full所以欧元和J1995可能01;8ab -缩短组胺激发试验用于职业性气道疾病的研究。我们评估了安全性，定义为一秒钟用力呼气量(FEV1)下降不超过40%。对投诉的发生、测试结果的可重复性以及节省的平均时间进行了测量。采用标准方案，包括30秒潮汐呼吸，浓度连续翻倍，从1到32毫克。ml-1组胺。无反应性气道症状的受试者起始浓度为4 mg.ml-1。FEV1下降<6%时，跳过一个浓度步骤(浓度增加四倍)。当FEV1下降至少18%时终止试验。共有697名受试者进行了测试。 All subjects with a provocative concentration of histamine producing a 20% decrease in FEV1 (PC20) value of < or = 4 mg.ml-1 (n = 16) started at the lowest concentration. Six subjects reached a > or = 20% decrease in FEV1 (range 21-24%) after a fourfold increase in concentration. Five subjects had a decrease in FEV1 of greater than 40%, and this decrease occurred after a doubling concentration. Cough, flushing, and chest tightness were noted in 18% of the subjects. In 56% of the tested subjects, the shortest provocation scheme (phosphate solution followed by 4, 16 and 32 mg.ml-1 histamine) was applied, resulting in a time reduction of nearly 50% per test, and reducing the time needed to complete the study from 5 to 3 months. The shortened test was repeatable within one concentration difference.(ABSTRACT TRUNCATED AT 250 WORDS)