TY -的T1 -缩短组胺的使用和安全挑战测试在一个职业研究摩根富林明-欧洲呼吸杂志》乔和J SP - 737 LP - 741欧元六世- 8 - 5盟克雷默盟——朋友,TM AU -欧登泽尔曾M盟——Kerkhof M AU - de Monchy詹盟——Rijcken采用缩短的组胺激发试验对职业性气道疾病进行了研究。我们评估了安全性，定义为一秒内用力呼气量(FEV1)的减少不大于40%。测量了投诉的发生情况、测试结果的可重复性以及节省的平均时间。采用了一个标准方案，包括30秒潮汐呼吸，浓度从1到32毫克连续加倍。ml-1组胺。无气道超反应迹象的受试者从4mg .ml-1开始。如果FEV1的下降是<6%，跳过一个集中步骤(浓度提高了4倍)。当FEV1下降至少18%时终止试验。总共有697名受试者进行了一次测试。 All subjects with a provocative concentration of histamine producing a 20% decrease in FEV1 (PC20) value of < or = 4 mg.ml-1 (n = 16) started at the lowest concentration. Six subjects reached a > or = 20% decrease in FEV1 (range 21-24%) after a fourfold increase in concentration. Five subjects had a decrease in FEV1 of greater than 40%, and this decrease occurred after a doubling concentration. Cough, flushing, and chest tightness were noted in 18% of the subjects. In 56% of the tested subjects, the shortest provocation scheme (phosphate solution followed by 4, 16 and 32 mg.ml-1 histamine) was applied, resulting in a time reduction of nearly 50% per test, and reducing the time needed to complete the study from 5 to 3 months. The shortened test was repeatable within one concentration difference.(ABSTRACT TRUNCATED AT 250 WORDS) ER -