RT期刊文章SR电子T1使用和安全的缩短组胺挑战试验职业研究JF欧洲呼吸杂志Jo EUR Respir J FD欧洲呼吸学会SP 737 OP 741 VO 8是5 A1 Kremer，AM A1 Pal，TM A1 Oldenziel，188bet官网地址M A1 Kerkhof，M A1 de Monchy，JG A1 Rijcken，B YR 1995 UL //www.qdcxjkg.com/content/8/5/737.abstract Ab缩短的组胺挑战试验用于职业气道的研究疾病。我们评估了安全性，定义为在一秒钟（FEV1）的强制呼气量的缺失，大于40％。征集的发生，测量测试结果的可重复性和节省的平均时间。使用标准方案，其包含30秒的潮汐呼吸，其序列倍增浓度为1至32mg.ml -1组胺。没有迹象的受试者在4毫克-ML-1开始。如果FEV1的减少<6％，则跳过浓度步骤（浓度的四倍增加）。当FEV1的减少至少为18％时，试验终止。共有697名受试者进行了测试。 All subjects with a provocative concentration of histamine producing a 20% decrease in FEV1 (PC20) value of < or = 4 mg.ml-1 (n = 16) started at the lowest concentration. Six subjects reached a > or = 20% decrease in FEV1 (range 21-24%) after a fourfold increase in concentration. Five subjects had a decrease in FEV1 of greater than 40%, and this decrease occurred after a doubling concentration. Cough, flushing, and chest tightness were noted in 18% of the subjects. In 56% of the tested subjects, the shortest provocation scheme (phosphate solution followed by 4, 16 and 32 mg.ml-1 histamine) was applied, resulting in a time reduction of nearly 50% per test, and reducing the time needed to complete the study from 5 to 3 months. The shortened test was repeatable within one concentration difference.(ABSTRACT TRUNCATED AT 250 WORDS)