Extract
Bronchopulmonary dysplasia (BPD) is the most frequent morbidity of preterm birth and is characterised by abnormal or arrested pulmonary development. Current definitions of BPD suffer from the limitation that they are based on treatment at specific time points [1, 2]. Lung mechanics may provide continuous markers of lung disease, independent from unit policies, which could be repeated over time during the evolving phase or follow-up.
Abstract
Respiratory system resistance and reactance assessed at 36 weeks post-menstrual age by the forced oscillation technique are sensitive functional markers of the severity of lung disease in former preterm infants https://bit.ly/3rZBq6z
Acknowledgements
We acknowledge Nicole Wellauer (Dept of Neonatology, University Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland) and Abedulrhman S. Abdelfattah (UO Neonatologia e Terapia Intensiva Neonatale, Fondazione Monza e Brianza per il Bambino e la sua Mamma (MBBM), Monza, Italy) for their support in performing the measurements.
Footnotes
Conflict of interest: E. Zannin and R.L. Dellacà report that Politecnico di Milano received research grants from Vyaire and licensed a patent for using FOT to assess lung volume recruitment to Vyaire, outside the scope of this study. R.L. Dellacà also reports stocks in Restech srl, a spin-off company producing lung function test devices. R.P. Neumann and S. Schulzke report equipment and disposables given by Acutronic to UKBB to perform the measurements. C. Rigotti and M.L. Ventura have nothing to disclose.
Support statement: E. Zannin was supported in this work by a European Respiratory Society long-term fellowship (LTRF 2015-4459). This work was supported by the Swiss Kommission für Technologie und Innovation (KTI, grant number 25768.2 PFLS). ACUTRONIC Medical Systems AG provided the device and disposables to perform the measurements at University Children's Hospital Basel UKBB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the paper. Funding information for this article has been deposited with the Crossref Funder Registry.
- Received December 2, 2021.
- Accepted February 9, 2022.
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