提取
细胞外囊泡是细胞释放的纳米级(20 - 1000nm)膜结构,在生理和病理过程中都发挥着重要作用。根据胞外囊泡的大小可分为小囊泡(sev;<200 nm,也称为外泌体)和介质(mev;>200 nm,也称为微泡)[1]。考虑到细胞外囊泡的含量和生物来源[2],可能会成为个性化药物的靶点。的确,在痰上清、黏液、上皮内壁液、肺循环和支气管肺泡灌洗液等各种生物液中检测到的细胞外囊泡是研究呼吸系统疾病病理生理学和发现生物标志物的独特工具[2,3]。
摘要
在呼出的呼吸凝结物和诱导的痰上清液中鉴定和表征的中小型细胞外囊泡可以提供严重哮喘和COPD患者的病理生理洞察和新型生物标志物https://bit.ly/3fiTnXY
脚注
作者贡献:D. Lucchetti为该著作的数据获取和分析提供了大量贡献;对重要知识内容进行了批判性的修改;批准稿件的最终版本出版;并同意对工作的所有方面负责,以确保与工作任何部分的准确性或完整性相关的问题得到适当的调查和解决。G. Santini为该工作的数据获取和分析作出了重大贡献;对重要知识内容进行了批判性的修改;批准稿件的最终版本出版;并同意对工作的所有方面负责,以确保与工作任何部分的准确性或完整性相关的问题得到适当的调查和解决;L. Perelli为该工作提供了大量的数据获取和分析;对重要知识内容进行了批判性的修改; approved the final version of the manuscript to be published; and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. C. Ricciardi-Tenore provided substantial contributions to the acquisition and analysis of data for the work; revised the manuscript critically for important intellectual content; approved the final version of the manuscript to be published; and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. F. Colella provided substantial contributions to the acquisition and analysis of data for the work; revised the manuscript critically for important intellectual content; approved the final version of the manuscript to be published; and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. N. Mores provided substantial contributions to the interpretation of data for the work; revised the manuscript critically for important intellectual content; approved the final version of the manuscript to be published; and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. G. Macis provided substantial contribution to the design of the work; revised the manuscript critically for important intellectual content; approved the final version of the manuscript to be published; and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. A. Bush provided substantial contributions to the interpretation of data for the work; revised the manuscript critically for important intellectual content; approved the final version of the manuscript to be published; and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. A. Sgambato provided substantial contributions to the conception, design of the work and interpretation of data for the work; revised the manuscript critically for important intellectual content; approved the final version of the manuscript to be published; and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. P. Montuschi provided substantial contributions to the conception and design of the work and interpretation of data for the work; drafted the manuscript and revised it critically for important intellectual content; approved the final version of the manuscript to be published; and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
利益冲突:卢凯蒂没有什么可透露的。
利益冲突:桑蒂尼没有什么可透露的。
利益冲突:L. Perelli没有什么可披露的。
利益冲突:C. ricciardie - tenore没有什么可透露的。
利益冲突:F. Colella没有任何披露。
利益冲突:N.摩尔斯没有什么可透露的。
利益冲突:G. Macis无需披露。
利益冲突:A.布什无需披露。
利益冲突:A. SGAMBOT没有什么可披露的。
利益冲突:P.蒙图斯基没有什么可披露的。
支持声明:这项研究由意大利罗马圣心天主教大学资助;学术授予2018 - 2019。
- 已收到2020年8月5日。
- 接受2021年3月22日。
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