提取
体部立体定向放射治疗(SBRT),也称为立体定向放射治疗烧蚀,其特征在于作为由施加由高分辨率成像引导的外部聚焦光束到目标定义明确的小肿瘤[1]进行非侵入性的高度精确放疗。由于它的高的局部控制和存活率具有可接受的毒性的,SBRT已经成为用于治疗早期非小细胞肺癌(NSCLC)谁是不适合外科手术[2]的患者指南推荐的选择。然而,最近,SBRT还在治疗可操作的患者早期NSCLC施加了巨大的挑战手术[3]。然而,在没有完成的随机对照试验,对SBRT的疗效与手术比较治疗早期NSCLC目前现有的证据都来自与倾向得分匹配分析[4]观察研究。最近的一项研究由detillon等。[5]比较了SBRT与功效胸腔镜(VATS)肺叶切除术用于通过将倾向得分匹配分析在老年患者中治疗I期NSCLC。They included a total of 792 elderly patients (≥65 years old) with clinical stage I NSCLC undergoing SBRT or VATS lobectomy. In the analysis of unmatched cohorts, with significant baseline characteristics imbalance between the two groups, they found that VATS lobectomy yielded significantly better overall survival than SBRT (77 months与38 months; p<0.001). In the analysis of matched cohorts, with well-balanced characteristics between the two groups, VATS lobectomy yielded similar overall survival to SBRT in the first 15 months of follow-up, but significantly better overall survival than SBRT after 15 months of follow-up in both primary and secondary analyses with different matching covariates [5]. Therefore, their study again added to the evidence that patients with clinical stage I NSCLC receiving VATS lobectomy had better overall survival than patients receiving SBRT.
抽象
肺叶切除应保持第一选择用于治疗早期非小细胞肺癌http://bit.ly/2M982Il
脚注
利益冲突:H-Y。邓有没有透露。
利益冲突:问:周有没有透露。
- 收到2019年3月31日。
- 公认2019年4月9日。
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