抽象的
年代leep is markedly altered in intensive care unit (ICU) patients and may alter respiratory performance. Our objective was to assess the impact of sleep alterations on weaning duration.
We conducted a prospective physiological study at a French teaching hospital. ICU patients intubated for at least 24 h and difficult to wean were included. Complete polysomnography (PSG) was performed after the first spontaneous breathing trial failure. Presence of atypical sleep, duration of sleep stages, particularly rapid eye movement (REM) sleep, and electroencephalogram (EEG) reactivity at eyes opening were assessed by a neurologist.
在45例研究的患者中,有20名(44%)的睡眠不可根据标准标准进行分类。非典型睡眠患者(中位数(四分位数)5(2-8),PSG和拔管之间断奶的持续时间明显更长相对2(1–2) days; p=0.001) and in those with no REM sleep compared with the others. Using multivariate logistic regression analysis, atypical sleep remained independently associated with prolonged weaning (>48 h after PSG). Altered EEG reactivity at eyes opening was a good predictor of atypical sleep.
我们的结果首次表明大脑功能障碍可能会影响自发呼吸的能力。
抽象的
ICU patients under mechanical ventilation with altered sleep had markedly longer weaning duration than did othershttp://ow.ly/BJip30jjag5
Footnotes
这项研究已注册Clinicaltrials.gov带有标识符NCT02920281。
作者贡献:A.W。Thille起草了这项工作,并为数据的分析和解释做出了重大贡献。F. Reynaud,S。Barrau,D。Marie,L。Rousseau,C。Rault,V。Diaz,J-C。Meurice,R。Coudroy和J-P。弗拉特(Frat)获得了数据,对重要的智力内容进行了严格修改,并最终批准了要发布的版本。A.W.Thille,R。Robert和X. Drouot设计了这项工作,解释了这项工作的数据,对重要的知识内容进行了严格的修订,并最终批准了要发布的版本。
利益冲突:R。Coudroy报告了法国卫生部,Bourse Aadairc和Bourse Le Nouveau蛋souffle的赠款,在提交的工作之外。J.P。Frat报告了Fisher&Paykel Healthcare的个人费用,非财务支持以及其他个人费用,以及个人费用以及SosOxygène的个人费用,在提交的工作之外。
- ReceivedDecember 4, 2017.
- 公认February 26, 2018.
- 版权©2018人队