Extract
体育活动(PA)是慢性阻塞性肺疾病(COPD)的相关结果指标。低PA是普遍的,并驱动预后[1]。不幸的是,PA的决定因素及其随着时间的变化知之甚少[1]。PA随着时间的流逝而随着肺功能和健康状况的恶化而逐渐下降的事实表明,PA下降可能是由于疾病的进展,特别是由于急性加重[3]。据报道,在需要住院治疗的严重加重和卧床治疗的恶化[5,6]中,急性减少了PA的急性减少。出院后1个月,已经显示出持续的PA降低[4],而在社区治疗的加重后,PA几乎恢复到稳定的水平[6]。一项研究发现,在研究前的12个月中,患有两种或更多病史的患者的PA下降速度更快[5]。该分析没有针对协会的混杂因素调整(e.g.airflow obstruction, symptom burden) or external variables influencing PA (e.g.气候)。也可以说,PA的较大下降是由于基线时健康状况较低。尽管PA是COPD患者的重要结果,但对患者在PA的经历中的恶化作用知之甚少。重要的是,活动期间的活动和困难都是PA限制的概念不可或缺的[7]。本分析的目的是评估恶化的数量和严重性与PA和PA经验的变化之间的关联。
抽象的
加重了negative impact on long-term daily physical activity of COPD patientshttp://ow.ly/olgl30hkdml
Acknowledgements
我们感谢主动项目伦理委员会,顾问委员会和患者输入平台的投入。积极主动的财团成员如下:纳塔莉·伊万诺夫(Nathalie Ivanoff)(西班牙巴塞罗那阿尔米尔(Almirall));Niklas Karlsson和Solange Corriol-Rohou(瑞典哥德堡Astrazeneca AB);伊恩·贾罗德(Ian Jarrod)(英国伦敦英国肺基金会);Damijen Erzen(Boehringer Ingelheim,Nieder-Ingelheim,德国);Mario Scuri和Roberta Montacchini(Chiesi Farmaceutici S.A.,意大利帕尔马);保罗·麦克布赖德(Paul McBride)(Choice Healthcare Solutions,Hitchin,UK);纳迪亚·卡梅尔(Nadia188bet官网地址 Kamel)(欧洲呼吸学会,瑞士洛桑);Maggie Tabberer(英国Uxbridge,Glaxosmithkline);Thierry Troasters,Wim Janssens,Heleen Demeyer和Fabienne Dobbels(比利时鲁汶市的Katholieke Universiteit Leuven); Judith Garcia-Aymerich (ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain); Pim de Boer (Netherlands Lung Foundation, Amersfoort, The Netherlands); Karoly Kulich (Novartis, Basel, Switzerland); Michael I. Polkey and Nick S. Hopkinson (Royal Brompton and Harefield NHS Foundation Trust, London, UK); Ioannis Vogiatzis (Thorax Research Foundation, Athens, Greece); Enkeleida Nikai (UCB, Brussels, Belgium); Thys van der Molen and Corina De Jong (University Medical Center, Groningen, The Netherlands); Roberto A. Rabinovich and Bill MacNee (University of Edinburgh, Edinburgh, UK); Milo A. Puhan and Anja Frei (University of Zurich, Zurich, Switzerland).
脚注
Support statement: The PROactive project is funded by the Innovative Medicines Initiative Joint Undertaking (IMU JU) #115011. This work was supported by the Flemish Research Foundation (grant # G.0871.13). H. Demeyer is the recipient of a joint ERS/SEPAR Fellowship (LTRF 2015) and is a post-doctoral research fellow of the FWO-Flanders. Z. Louvaris is the recipient of an ERS fellowship (LTRF 2016) and is a post-doctoral research fellow of the FWO-Flanders. ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. Funding information for this article has been deposited with theCrossref Funder Registry.
Conflict of interest: Disclosures can be found alongside this article atwww.qdcxjkg.com
- 已收到June 23, 2017.
- Accepted2017年10月27日。
- 版权所有©ERS 2018