摘要
使用高压氧(HBO)治疗与潜水无关的疾病的处方正在增加。肺氧毒性是众所周知的,但累积氧暴露的影响,相应的标准HBO治疗方案之前没有量化。20例患者(10名男性)以240kpa分压氧治疗21例,每天90分钟。研究开始时,所有患者均无肺部疾病病史,胸片和肺功能均正常。在HBO治疗前、治疗期间的第7天、第14天和第21天以及治疗后的第3-4周测定动态肺容积、强迫呼气流量和肺中一氧化碳(TL、CO)的转移因子。四名患者(一名男性)报告在最后一周的治疗期间无效咳嗽。在HBO治疗期间,一秒钟内的强迫呼气容积(FEV1) (p<0.001)、平均强迫呼气中流量率(FEF25-75%) (p<0.001)和强迫肺活量(FVC)的50%和75%的呼气流量均逐渐减少。第21天FEV1减少4.4+/-1.7%,FEF25-75%减少10.3+/-6.1%。治疗4周后,部分恢复正常。FVC和呼气流量峰值(PEF)无变化。 TL,CO was slightly reduced on day 21 of treatment only (p<0.01) and fully normalized 1 month later. A reduction in small airways conductance is consistent with other studies where total oxygen exposures have been below the limit causing toxic pulmonary effects traditionally measured as a reduction in vital capacity. This effect is not considered to be of any clinical significance for patients treated with hyperbaric oxygen unless repeated treatment series are to be given.