TY -的T1 -影响标准的高压氧治疗肺功能摩根富林明议定书-欧洲呼吸杂志》乔和J SP - 1442 LP - 1445欧元六世- 12 - 6盟于E盟——Aanderud L盟——Aasen结核病Y1 - 1998/12/01 UR - //www.qdcxjkg.com/content/12/6/1442.abstract N2的处方高压氧(HBO)治疗疾病与潜水正在增加。肺氧毒性是众所周知的，但与标准HBO治疗方案相对应的累积氧暴露的影响以前还没有被量化过。20例患者(10例男性)接受21次高压氧治疗，分压为240kpa，每天90分钟。在研究开始时，所有人的胸片和肺功能都正常。在高压氧治疗前、治疗中第7、14和21天以及治疗后3-4周分别测量了动态肺容积、用力呼气流量和肺对一氧化碳(TL、CO)的转移因子。4名患者(1名男性)在治疗的最后一周报告了非生产性咳嗽。在HBO治疗期间，1秒用力呼气量(FEV1) (p<0.001)、平均用力呼气中流量(FEF25-75%) (p<0.001)和用力肺活量(FVC)达到50%和75%时的用力呼气流量逐渐减少。第21天FEV1降低4.4+/-1.7%，FEF25-75%降低10.3+/-6.1%。治疗4周后部分恢复正常。FVC和呼气峰值流量(PEF)均无变化。 TL,CO was slightly reduced on day 21 of treatment only (p<0.01) and fully normalized 1 month later. A reduction in small airways conductance is consistent with other studies where total oxygen exposures have been below the limit causing toxic pulmonary effects traditionally measured as a reduction in vital capacity. This effect is not considered to be of any clinical significance for patients treated with hyperbaric oxygen unless repeated treatment series are to be given. ER -