文摘
高渗盐水喷雾吸入引起的痰正越来越多地用于监控在哮喘气道炎症。本研究的目的是评估测量的重复性炎症细胞和可溶性标记在整个痰样本获得的痰诱导患者有轻微和严重哮喘。十二个轻微,患者过敏性哮喘没有吸入类固醇治疗和九是严重的患者,接受吸入皮质类固醇治疗的过敏性哮喘研究在两天的时间里至少2天。整个痰液样本,吸入诱导的高渗盐水(4.5%),均质,并分析了微分细胞数量和浓度的白蛋白,纤维蛋白原,interleukin-8(引发)和嗜酸性粒细胞阳离子蛋白(ECP)。重复性是表示为组内相关系数(Ri),以及可重复性(CR)的细胞比例系数或翻倍浓度。两个样本轻度哮喘患者中超过80%的鳞状细胞并被排除在分析之外。两组细胞的可重复性差计算组合是:中性粒细胞,Ri = 0.57和CR = 31.0;嗜酸性粒细胞,Ri = 0.85和CR = 12.4;淋巴细胞,Ri = 0.76和CR = 6.9。流体相的可重复性测量是:白蛋白,Ri = 0.71和CR = 3.2; for fibrinogen, Ri = 0.88 and CR = 2.8; for IL-8, Ri = 0.66 and CR = 2.2; and for ECP, Ri = 0.82 and CR = 1.1. We conclude that the repeatability of cellular and soluble markers of inflammation in induced sputum from patients with mild and moderate-to-severe asthma is satisfactory. Hence, induced sputum, processed by using the whole expectorated sample, seems to be a valuable method to monitor airway inflammation in asthma.