Extract
We commend Adderleyet al.[1]用于评估支气管肺泡灌洗液(BALF)淋巴细胞增多的荟萃分析,以诊断慢性超敏性肺炎。区分慢性超敏性肺炎(CHP)与特发性肺纤维化(IPF)具有预后和治疗意义。由于没有使用肺活检作为金标准来回答这个问题的研究,因此作者必须依靠观察性研究,其中一些研究使用BALF淋巴细胞增多症作为诊断CHP的标准。作者承认,这可能导致诊断测试掺入偏差。掺入偏见可能会导致对BALF淋巴细胞增多症与CHP之间关联的估计值,或者在有偏见的结论中,支气管肺泡灌洗(BAL)淋巴细胞计数可以统治或排除CHP。这是因为当将研究的测试用作诊断感兴趣状况的黄金标准的一部分时,特异性和敏感性可能会受到影响[2]。
Abstract
Bronchoalveolar lavage fluid lymphocytosis may be useful in the diagnosis of chronic hypersensitivity pneumonitis. However, reanalysis after eliminating studies that used bronchoalveolar lavage lymphocytosis as part of the diagnostic criteria is needed.https://bit.ly/34AmHmm
Footnotes
Conflict of interest: O. Moran-Mendoza has nothing to disclose.
Conflict of interest: M. Khalil has nothing to disclose.
- ReceivedNovember 27, 2020.
- AcceptedDecember 13, 2020.
- ©ERS 2021.
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