Extract
Nontuberculous分枝杆菌(特种加工)环境l pathogens causing disease in humans; however, not everyone exposed develops disease [1]. Those with underlying pulmonary diseases, persons over 60 years old and women have an increased risk for nontuberculous mycobacterial pulmonary disease (NTM-PD) [1, 2]. Bronchiectasis is a lung condition characterised by chronic airway dilation and inflammation, resulting in impaired mucus clearance, and is associated with NTM-PD [1–3]. Both NTM-PD and bronchiectasis are increasing in incidence in the USA [2, 3]. Although patients with bronchiectasis are at increased risk of acquiring NTM-PD [1, 2], the incidence of NTM-PD in these patients is not well described. Previous US Medicare data estimated those with bronchiectasis were 50- to 75-fold more likely to have a diagnosis of NTM-PD than those without bronchiectasis [4]. The objective of this analysis was to estimate the incidence of NTM-PD among US Medicare enrolees newly diagnosed with bronchiectasis over the age of 65 years.
Abstract
Incidence of NTM-PD was estimated among US Medicare beneficiaries newly diagnosed with bronchiectasis between 2006 and 2014. Overall incidence of NTM-PD was found to be as high as 1950 per 100 000 person-years.https://bit.ly/3iAr4o5
Acknowledgements
We thank Kevin Ng (OHSU) for technical support generating the datasets for analysis.
Footnotes
Conflict of interest: K.L. Winthrop reports grants from Insmed, Inc, AN2 Therapeutics, Paratek Pharmaceuticals, Redhill Biopharma; consulting fees from Insmed, Inc, AN2 Therapeutics, Paratek Pharmaceuticals, Redhill Biopharma, Spero Therapeutics; outside the submitted work. E. Henkle reports consulting fees from and participation on an advisory board for AN2 Therapeutics; outside the submitted work. All other authors have nothing to disclose.
- ReceivedJanuary 4, 2022.
- AcceptedMarch 17, 2022.
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