摘要
转移因子(TL)随肺泡体积(VA)的变化而变化,但与一氧化碳转移系数(KCO (TL/VA))的变化方式不同。本文考虑了另外两个简单的模型(一个线性模型和一个指数模型),这两个模型可能将TL标准化为VA,并提出了以下问题:1)这两个模型是否有效?2)什么是合适的参考值?3)模型有用吗?测量并比较了不同吸气深度受试者和不同肺大小受试者之间的TL与VA的关系。研究对象为无症状、不吸烟的白种人成年人,包括实验室评估的31名男性和人口研究的503名男性和女性参与者。TL在VA上的线性偏回归系数(L用体温、大气压力和水饱和度(BTPS)校正)以米为单位标准化的身高(H),在受试者内部和受试者之间相似;系数适用于VA的大范围值。这不是指数模型的情况。以SI单位计算的雄性和雌性参考方程为:TL = 11.52 H + 2.72 VA.H-2 - 0.051 Age -12.35。相对标准偏差1.17; and TL = 4.87 H + 2.29 VA.H-2 - 0.019 Age -3.03. RSD 0.92, respectively. The residual standard deviations (RSD) about the new relationships were less than in other series. The new linear model could account for much of the variation between different published reference values for TL; it could be useful clinically, in circumstances when VA deviates from the norm. The model does not explain differences in TL associated with gender. Inclusion of VA.H-2 as a covariate in the reference equation for transfer factor, in addition to age and height, improves the accuracy of prediction of normal transfer factor compared with current reference values; its use suggests that some of the differences between published values is due to the volume term. The equations can be used clinically, and eliminate the need for carbon monoxide transfer coefficient.