摘要
对阻塞性睡眠呼吸暂停综合征患者,电刺激上气道肌肉组织是否可以作为一种有益的治疗方式,目前存在争议。上呼吸道(UAW)肌肉活动增加可降低离体UAW犬的上呼吸道阻力(Ruaw)。在本研究中,我们评估了UAW肌肉收缩对麻醉犬通过部分和完全阻塞的UAW自主呼吸的影响。测量气流和声门上压,得到Ruaw。通过经皮植入咽粘膜下层的橡皮球囊的吸入可调节Ruaw,从而产生部分或完全阻塞。金属丝电极双侧植入颏舌肌(GG)、颏舌骨肌(GH)、胸甲状肌(ST)和胸舌骨肌(SH)进行电刺激(ES),植入鼻翼进行肌电图(EMG)记录。在部分或完全UAW阻塞之前和期间对每块肌肉进行三级电刺激。颏舌肌和颏舌骨肌刺激均可显著降低Ruaw,其中在部分梗阻时最明显,Ruaw由54 +/- 11降低至14 +/- 3,由74 +/- 12降低至31 +/- 5 cmh2o -1。年代,分别。在低电压下,刺激颏舌肌比刺激颏舌肌更有效。此外,电刺激颏舌肌而非颏舌骨肌可解除全梗阻。 In contrast, electrical stimulation of the sternohyoid and sternothyroid produced no significant change in Ruaw. These findings demonstrate that selective UAW dilatory muscle contraction in spontaneously breathing anaesthetized dogs reduces Ruaw in the presence of UAW obstruction and releases UAW occlusion, with the genioglossus being the most effective muscle. This favours further attempts to investigate the benefits of electrical stimulation of selected upper airway muscles in the treatment of obstructive sleep apnoea syndrome.