ty -jour t1-带有上气道阻塞的麻醉犬的电动扩张肌降低咽部抗性 - 欧洲呼吸杂志JO -EUR RESSIR J SP -1537 LP -1537 LP -1542 VL -8 IS -9 AU -BISHARA -BISHARA -BISHARA,H AU -ODEH,H AU -ODEH -ODEH -ODEH -ODEH,M au -schnall,rp au -gavriely,n au -oliven,y1-1995/09/01 ur -http://www.qdcxjkg.com/content.com/content/8/9/1537/1537.abstract n2-有电流关于上呼吸道肌肉的电刺激是否可以使用我们是阻塞性睡眠呼吸暂停综合征患者的有益治疗方式的争议。上呼吸道(UAW)的肌肉活动增加可降低狗的孤立UAW中的UAW耐药性(RUAW)。在本研究中,我们评估了UAW肌肉收缩对体内呼吸的麻醉犬对UAW通气的影响,并通过部分自发呼吸,并完全阻塞UAW。测量气流和上压力以获得RUAW。Ruaw可以通过在咽粘膜下经皮植入的橡胶球囊吸入来调节Ruaw,以产生部分或完全的阻塞。将电线电极双侧植入Geniogloss(GG),基因法(GH),胸甲甲状腺(ST)和胸骨壳(SH)肌肉(ES),以及用于剧本(EMG)记录的ALAE NASI。在部分或完整的UAW障碍物之前和期间,将三个水平的电刺激传递到每个肌肉。Genioglossus和Geniohoid刺激均导致RUAW显着降低,这在部分阻塞期间最为明显,将RUAW从54 +/- 11降低到14 +/- 3,从74 +/- 12降低到31 +/- 5 CMH2O。L-1.S。在低电压下,刺激天才比刺激基因法比在减少RUAW时更有效。 Furthermore, electrical stimulation of the genioglossus but not of the geniohyoid released total obstruction. In contrast, electrical stimulation of the sternohyoid and sternothyroid produced no significant change in Ruaw. These findings demonstrate that selective UAW dilatory muscle contraction in spontaneously breathing anaesthetized dogs reduces Ruaw in the presence of UAW obstruction and releases UAW occlusion, with the genioglossus being the most effective muscle. This favours further attempts to investigate the benefits of electrical stimulation of selected upper airway muscles in the treatment of obstructive sleep apnoea syndrome. ER -