抽象的
泼尼松龙在控制支气管哮喘的喘息袭击时非常有效,但其机制和白酮B4的致病作用仍然不清楚。在支气管哮喘的临床过程中,在支气管哮喘的临床过程中测量白硫二乙烯B4的变化,有或没有水溶性泼尼松龙治疗。从患者的桡动脉三次从患者的桡动脉中吸出两次血液:1)在缓解期间;2)在哮喘发作入院时入院;3)入院后2天,用静脉内泼尼松龙治疗(1,000 mg.day-1)。通过色谱分级和放射免疫测定检测白酮B4。在11例哮喘患者中,三次白三烯B4水平分别为26.8(10.7),106.0(39.9)和51.6(20.2)pG.ML-1(平均值(SD))。相反,10个正常对照的平均白三烯B4水平为35.9(10.5)PG.ML-1。白酮B4水平在没有泼尼松龙治疗的缓解和攻击之间的差异显着不同,并且在没有泼尼松龙治疗的攻击之间。平均动脉二氧化碳(PACO2)值为4.8(0.4)KPa(36.0(36.0),6.1(0.4)KPa(45.6(2.9)毫米)和5.5(0.3)KPA(41.6(2.0)mmHg)。 There were significant differences between these mean PaCO2 values. The mean leukotriene B4 levels on the three occasions were correlated with the mean PaCO2 values. Thus, leukotriene B4 levels in arterial blood reflect the severity of asthmatic attacks and may be affected by intravenous prednisolone.