摘要
识别慢性阻塞性肺疾病(COLD)患者的亚群以确定疾病结局,以及可能的治疗效果是一个临床感兴趣的领域。目前,尚不清楚哪些感冒患者最有可能受益于抗炎治疗。我们在社区居住的男性样本中调查了这个问题。在本研究中,研究了894名男性受试者(平均年龄60岁;41 - 90岁)。考虑的症状是哮喘、持续哮鸣、呼吸困难、慢性咳嗽和痰。醋甲胆碱反应是定义为一个挑衅剂量产生一秒钟用力呼气量下降20% (PD20FEV1) < = 8.6 mumol,积极的皮肤试验的鞭痕直径>或减法后= 5毫米直径的鞭痕反应控制甘油,嗜酸性粒细胞计数为>或= 275细胞。外周血Mm-3。慢性症状(优势比(OR) 2.0;95%可信区间(CI) 1.4-2.7)、气道反应性(OR 1.7; CI 1.1-2.7), and the combination of symptoms and airway responsiveness (OR 3.4; CI 2.0-5.6) were positively and significantly related to peripheral-blood eosinophil counts. These relationships remained significant after adjustment for the effects of age and smoking, and after exclusion of asthmatic subjects. Symptoms and airway responsiveness combined were not significantly related to neutrophil counts.(ABSTRACT TRUNCATED AT 250 WORDS)