摘要
本研究的目的是评估职业暴露于低水平的气道刺激物和气道对组胺的反应性之间的关系。根据英国医学研究委员会(BMRC)的问卷调查,对688名男性工人的症状患病率进行了评估。所有受试者均进行30秒潮汐呼吸挑战试验。气道高反应性(AHR)的定义是当<或= 32 mg时,1秒用力呼气量(FEV1)下降20%。ml-1组胺。根据工作职位和工作部门,将所有工作人员的暴露状况分为7组:1)参照组;2)白领;3) SO2, HCl, SO4(2-);4)聚酯蒸汽;5)油雾和油蒸气;6)聚酰胺和聚酯蒸汽; and 7) multiple exposures. Using multiple logistic regression, no association was found between the exposure groups and a higher prevalence of AHR. A higher prevalence was significantly associated with a low FEV1, a history of allergy, and the presence of chronic respiratory symptoms. Subjects in the SO2 group and the oil mist group with < or = 5 exposure years had a lower prevalence of AHR, probably due to pre-employment selection procedures. There was some trend for subjects with more than 5 yrs exposure to polyester vapour and to oil mist and to oil vapour to have a higher prevalence of AHR. Analyses using the dose-response slope according to O'Connor, revealed similar results and provides no additional information. We conclude that no association could be demonstrated between low grade exposure to airway irritants and airway hyperresponsiveness, and that further research is needed to elucidate this relationship.