抽象的
在哮喘的恶化和抗原攻击之后,尿液二酮E4(LTE4)增加。我们确定尿液LTE4排泄是否反映了哮喘患者气道中的硫叠肽白核菌。在八个哮喘受试者中吸入支支支气管纤维素剂量的白三烯C4(LTC4)或LTE4之后,测量尿LTE4浓度和1.5和3.5小时。吸入增加剂量的激动剂直至实现了35%的气道测量(SGAW)。在LTC4吸入后,SGAW的53 +/- 3%(平均+/- SEM)落下没有显着差异(63.1 ng几何平均值,GM,范围5.8-527.5 ng)和43 +/- 4%的秋季在吸入LTE4 7.94 NG / GM之后的SGAW(范围为132-3701 ng)。LTE4排泄速率从2.95(范围0.6-17.5)Ng.H-1至4.67(范围0.8-20)Ng.H-1以1.5小时,在LTC4吸入后显着增加;1.8(范围为0.07-6.7)Ng.h-1至6.9(范围2.9-27.3)Ng.h-1,在LTE4吸入后1.5小时;并从基线返回3.5小时。LTC4吸入剂的剂量与尿液中排出的LTC4的剂量(分别分别排出的LTE4(分别为r = 0.82和r = 0.72)之间的相关性。 The % recovery of LTE4 in the urine, of the total dose of inhaled LTC4 or LTE4 administered, was 6.9 +/- 4.1% and 0.8 +/- 0.3%, respectively. Thus, inhalation of bronchoconstricting doses of LTC4 or LTE4 alter urinary LTE4 excretion in a dose-dependent fashion. This indicates that urinary LTE4 can be used as a marker of sulphidopeptide leukotriene synthesis in the lungs of patients with asthma.