抽象
理由是:OPEP治疗时雾化给药或高渗盐水优惠同时使用,以降低综合治疗时间的潜力。气溶胶沉积显像进行了评估体内肺沉积从相比于单从喷雾器沉积耦合到OPEP装置的BAN(AEROECLIPSE * II)(Aerobika *)。
方法:Eight healthy subjects received albuterol (2.5 mg/3mL) admixed with 2 mCi of Tc-DTPA (Technetium-99m bound to diethylenetriaminepentaacetic acid) administered using the BAN alone and again when the BAN was combined with the OPEP device. Regional doses were then determined from anterior and posterior gamma camera images collected after delivery. Lung perimeters were defined using Cobalt-57 transmission scans and applied to Tc-DTPA deposition images. Results were expressed as a percentage of baseline counts.
结果:8名受试者(4男4女)的平均年龄为33岁。全肺沉积平均为31±13 vs 32±13%,分别为BAN和BAN+OPEP的加载剂量。
结论:药物从AEROECLIPSE * II BAN到肺部交付没有显著由Aerobika * OPEP设备的结合受到影响。这种疗法可以提供临床医生用于组合烟雾/ OPEP疗法的机会(即,在囊性纤维化患者),由此减少所需要的病人单独采取雾化器和OPEP处理的时间。
脚注
引用本文为:欧洲呼吸杂志2019;54:增刊。63,PA4529。
这是一个ERS国际会议摘要。没有全文版本。陪这个抽象而且材料可以是可在www.ers-education.org(仅ERS构件访问)。
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